| Grant number: | 21/13593-6 |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| Start date: | March 01, 2022 |
| End date: | April 30, 2026 |
| Field of knowledge: | Biological Sciences - Pharmacology - Cardiorenal Pharmacology |
| Principal Investigator: | Gilberto de Nucci |
| Grantee: | Antonio Tiago Silva Lima |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Associated research grant: | 19/16805-4 - Evaluation of the pathophysiological role of endothelial catecholamines, AP.TEM |
Abstract Electric Field Stimulation (EFS) is a technique in which an electrical stimulus is uniformly applied to isolated tissue in short-wave pulses. Depending on the mediators released by the EFS, tissue contraction or relaxation may occur. Initially, our research group demonstrated that stimulated contractions of Human Umbilical Cord Vessels (HUCV) depend on the presence of the endothelium and are not affected by tetrodotoxin, a sodium channel blocker used to prevent the release of mediators from nerve endings. Similar findings were found in reptiles, aorta of the tortoise Chelonoidis carbonaria and aorta of Crotalus durissus terrificus, Bothrops jararaca and Panterophis guttatus. Recently, the basal release of dopamine by HUCV endothelial cells was detected through pharmacological assays and by liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS). Dopamine acts in dopaminergic neurotransmission in the central nervous system, in the modulation of blood pressure by renal and vascular mechanisms, and is important in the modulation of cardiac function. LC-MS-MS analyzes also revealed a new vascular mediator to 6-nitrodopamine. 6-nitrodopamine is produced from the nitration of dopamine. Preliminary trials by our research group identified that 6-nitrodopamine has an important positive chronotropic effect in the right atrium of rats and in modulating their blood pressure. The aim of this work is to characterize and investigate the physiological role of the novel catecholamine 6-nitrodopamine in chronically treated rats. (AU) | |
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