Obesity, Sarcopenia, and Sarcopenic Obesity impact on health markers and quality of life in community-dwelling elderly frail women

• Grant number: 20/07098-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2022
• End date: August 31, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Ferreira Borba Neto
• Grantee: Alan Lins Fernandes
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Frailty phenotype is a multifactorial and one of the most important geriatric syndromes, described as a cumulative decline in various body systems that predisposes the individual to less resistance to stressors and greater vulnerability to fractures, falls, institutionalization and death. One of the main aspects of frailty phenotype is the loss of physical performance, dinapenia and Sarcopenia. Sarcopenia overlaps with the frailty and has been strongly associated with Obesity, particularly in elderly women, both Sarcopenia and Obesity exacerbate and maximize its effects, promoting an interdependent condition called Sarcopenic Obesity. Sarcopenic Obesity has not been elucidated and is shown to be better understood for its adverse effects. Notwithstanding, to date, there is no study that has evaluated the the impairment of Sarcopenic Obesity in frail elderly. Therefore, the aim of this study is to compare the impact of Obesity, Sarcopenia and Sarcopenic Obesity on functional performance, quality of life, and health markers in community-dwelling elderly frail women. One hundred-two elderly frail women (e 65 years old) will be selected, and allocated to one of the three groups: Obesity (n = 34), Sarcopenia (n = 34) or Sarcopenic Obesity (n = 34). Participants will be evaluated for gait speed test, lipid profile, inflammatory cytokines, bone metabolism, bone mineral density, and quality of life. All variables will be accessed using the Mixed Model (SAS) with Tukey's post hoc for multiple comparisons. Analysis of covariance (ANCOVA), adjusted for age, will be conducted with Tukey's post hoc. The level of significance will be 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES, ALAN L. L.; PEREIRA, ROSA M. R.. Frailty in the context of COVID-19 pandemic: A life-threatening condition. FRONTIERS IN MEDICINE, v. 9, p. 7-pg., 2022-08-24. (20/11102-2, 20/07098-0, 20/05752-4)

FERNANDES, ALAN L. L.; SALES, LUCAS P. P.; SANTOS, MAYARA D. D.; CAPARBO, VALERIA F. F.; MURAI, IGOR H. H.; PEREIRA, ROSA M. R.. Persistent or new symptoms 1 year after a single high dose of vitamin D-3 in patients with moderate to severe COVID-19. FRONTIERS IN NUTRITION, v. 9, p. 10-pg., 2022-09-13. (20/11102-2, 19/24782-4, 20/07098-0, 20/05752-4)