Controlled release of proteins from porous silica

• Grant number: 24/15251-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: September 30, 2025
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Marcia Carvalho de Abreu Fantini
• Grantee: Vitória Gabriely Fernandes Haydu
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 17/17844-8 - Nanostructured silica as a protective vehicle for vaccines and biomolecules, AP.TEM

Abstract

The goal of this work is the investigation of how the porous structure influences the encapsulation yield and release of proteins from two different ordered mesoporous silia (SMOs).In this study we will use the model protein BSA and crotoxin to determine the respective encapsulation yield and release dynamics. The main characterization techniques will be in-situ small angle X-ray scattering (SAXS) and nitrogen adsorption (NAI).