In vitro evaluation of the anti-inflammatory and antidiabetic activity of hydroethanolic extract of Cissus verticillata leaves

• Grant number: 25/11697-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: January 19, 2026
• End date: July 18, 2026
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Amanda Martins Baviera
• Grantee: Felipe Nunes Cardoso
• Supervisor: Eduarda das Gracas Rodrigues Fernandes
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: Universidade do Porto (UP), Portugal
• Associated to the scholarship: 23/03464-0 - Study of the antioxidant and antiglycation potential of the hydroethanolic extract of Cissus verticillata leaves in in vivo model system of obesity and in vitro model system of glycoxidative stress, BP.DD

Abstract

Diabetes mellitus (DM) is a chronic endocrine disease characterized by insulin resistance in target tissues and pancreatic dysfunction, where there is also the establishment of glyco-oxidative stress, marked by the generation of reactive species that lead to the progression of tissue damage. Type 2 DM is correlated with obesity, where exacerbated and harmful inflammatory responses are common. In the search for new therapies, techniques based on the inhibition of enzymes that participate in glucose metabolism are excellent alternatives for prospecting bioactives. Thus, this project aims to evaluate the performance of the hydroethanolic extract of Cissus verticillata leaves, its major compounds and metformin in an in vitro model of modulation of neutrophil activity, which mimics intense inflammatory response conditions, and in an in vitro model of inhibition of the enzymes ¿-amylase and ¿-glucosidase (AU)