Bispectral index, hemodynamic and respiratory effects of continuous infusion propofol associated or not to fentanyl in calves

Author(s)

Mauricio Deschk

• Document type: Doctoral Thesis
• Press: Botucatu. 2016-07-01.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu
• Defense date: 2015-11-06
• Advisor: Celso Antônio Rodrigues; Paulo Sergio Patto dos Santos

Abstract

The aim of this study was to evaluate the bispectral index and hemodynamic, respiratory and blood gas effects of continuous infusion of propofol with or without fentanyl in calves. Eight animals were used, with six to 12 months old, male Holstein calves, with an average weight of 123 ± 18 kg. All animals participated in both groups, respecting always a minimum interval of one week between the anesthetic procedures, the calves were randomly distributed between groups. They were induced to anesthesia with propofol at a dose of 5 mgkg-1 IV control group (GP) or propofol 4 mg kg-1 associated with fentanyl 0.001mgkg-1 IV fentanyl group (GF) and positioned in right lateral decubitus, where remained spontaneously breathing room air. Subsequently, the Anesthesia was maintained by continuous infusion of propofol at the rate of 0.6 mg kg-1 min-1 IV, with or without the infusion of fentanyl 0.001mg kg-1 hour-1. In both groups, drugs were administered through an infusion pump over 60 minutes. The measurements of hemodynamic parameters (HR, SAP, DAP, MAP, CO, CVP, mPAP, mPAPO, CI, SI, SVRI and PVRI), respiratory (ETCO2, f, SpO2,VME and VTE), blood gas(PaO2, PaCO2, SaO2, DB, pHandHCO3-) and bispectral index (BIS, SQI and EMG) were evaluated before anesthesia induction(MB), 15, 30, 45 and 60 minutes after the beginning of continuous infusion of drugs (M15, M30, M45 and M60, respectively). Hemodynamic parameters remained stable during the evaluate on period, no significant differences were observed between the groups in the respiratory variables and BIS, however, all animals presented respiratory acidosis. With the infusion of propofol associated or not with fentanyl the maintenance of the hemodynamic parameters was satisfactory with respiratory acidosis indicating, therefore, the use of mechanical ventilation (AU)

• FAPESP's process: 13/09469-1 - BISPECTRAL INDEX, HEMODYNAMIC AND RESPIRATORY EFFECTS OF CONTINUOUS INFUSION PROPOFOL ASSOCIATED OR NOT TO FENTANYL IN CALVES
• Grantee: Mauricio Deschk
• Support Opportunities: Scholarships in Brazil - Doctorate