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| Author(s): |
Livia Mendonça Munhóz Dati
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2017-05-22 |
| Examining board members: |
Luiz Roberto Giorgetti de Britto;
Fernando Rodrigues de Moraes Abdulkader;
Hudson de Sousa Buck;
Roberto de Pasquale;
Fulvio Alexandre Scorza
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| Advisor: | Luiz Roberto Giorgetti de Britto |
| Abstract | |
Parkinson\'s disease (PD) is a second most common neurodegenerative disease in the population, and the mechanisms involved in these are studied in animal models. There is evidence that some systems can modulate the development of PD. Transient potential channels (TRPs) and purinergic receptors seem to be involved in neurodegeneration and may contribute to the development of PD; on the other hand, kininas appear to be related to neuroprotection. The aim of this study was to evaluate the expression and the involvement of these membrane receptors in the 6-OHDA-induced PD model in mice (C57Bl / 6) injected with agonist (BK) and antagonist (HOE-140) of B2 receptor; antagonist of TRPM7 (Carvacrol); and in B2 knockout knockouts, by immunohistochemistry and Western blotting techniques. The data revealed modulation of these receptors in the model, and neuroprotection after TRPM7 blockade. Thus, we can suggest that all the receptors evaluated may be involved in the induction of the 6-OHDA model, and can be possible therapeutic targets for PD. (AU) | |
| FAPESP's process: | 13/06044-0 - Parkinson disease: possible involvement of kinin, purinergic and transient potential receptors. |
| Grantee: | Lívia Mendonça Munhoz Dati |
| Support Opportunities: | Scholarships in Brazil - Doctorate |