Effect of platelet rich-plasma pre or post-artificial insemination on the inflammatory reaction and fertlity rates in susceptible mares to persistent breeding-induced endometritis

Author(s)

Lorenzo Garrido Teixeira Martini Segabinazzi

• Document type: Master's Dissertation
• Press: Botucatu. 2016-11-16.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu
• Defense date: 2016-09-14
• Advisor: Marco Antonio Alvarenga

Abstract

The persistent breeding-induced endometritis (PBIE) is the main cause of decrease fertility in the horses, thereby causing significant impact in the horse’s market. The treatments commonly used for PBIE view only minimize the predisposing factors and do not act directly in the inflammatory process. Aiming to reduce the inflammatory response, recent studies have shown an increase in fertility of animals with PBIE when used immunomodulatory agents. A modulator of the inflammatory response that has been largely used in veterinary medicine is the platelet-rich plasma (PRP). This platelet concentrate contains many growth factors which act directly on inflammatory mediators, reducing process and promoting tissue repair. Several studies have shown that PRP is beneficial in the treatment of osteoarticular and tendon inflammations, modulating inflammation and accelerates the regeneration of injured tissue. More recently some researchers have demonstrated the beneficial effect of PRP in intrauterine treatment of mares. Thus, the present study aimed to do a literature review on the aspects related to PBIE, as well as the PRP and its mechanism of action. (AU)

• FAPESP's process: 15/00150-8 - EFFECT OF USING PLATELET-RICH PLASMA PRE OR POST ARTIFICIAL INSEMINATION ON THE INFLAMMATORY RESPONSE AND FERTILITY RATES IN SUSCEPTIBLES MARES TO POST-MATING INDUCED ENDOMETRITIS
• Grantee: Lorenzo Garrido Teixeira Martini Segabinazzi
• Support Opportunities: Scholarships in Brazil - Master