In situ evaluation of the anti-erosive effect of the association of sodium fluoride with propylene glycol alginate

Author(s)

Letícia Oba Sakae

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO)
• Defense date: 2019-03-25

Examining board members

Taís Scaramucci Forlin; Alessandra Buhler Borges; Thiago Saads Carvalho; Cecilia Pedroso Turssi

• Advisor: Taís Scaramucci Forlin

Abstract

The aim of this study was to evaluate the anti-erosive effect of solutions containing sodium fluoride (F: 225 ppm F-), sodium fluoride + stannous chloride (F+Sn: 225 ppm F- + 800 ppm Sn2+), sodium fluoride + propylene glycol alginate (F+PGA: 225 ppm F- + 0,1% PGA), and distilled water (negative control), using a four-phase, split mouth, single blind, crossover in situ trial. Twelve subjects participated in the study after signing a written informed consent. In each study phase, the subjects used removable mandible devices containing four enamel specimens, which were submitted to an erosion-abrasion or erosion-remineralization cycling model (split mouth) of five days. The erosion-abrasion cycling consisted of 5 min extra-oral immersion in 1% citric acid (pH=2.6), followed by 120 min remineralization in situ. This procedure was repeated 4x/day. Treatment with test solutions was performed 2x/day, after the first and the last erosive challenges. Before treatment, toothbrushing was perfomed with an eletric toothbrush and a toothpaste slurry (1450 ppm F) for 5 s, in a total of 2 min exposure to the slurry. For the groups subjected to erosionremineralization, the same cycling described before was performed, however, the specimens were only exposed to the toothpaste slurry for 2 min, without brushing. At the end, enamel surface loss (SL, in ?m) was evaluated with optical profilometry. Data were analyzed with 2-way ANOVA repeated measures and Fisher tests (?=0,05). For both conditions (erosion and erosion-abrasion), F+Sn presented significantly the lowest SL, followed by F+PGA, F, and distilled water, which did not differ from each other. Groups submitted to erosion-abrasion presented a higher SL in comparison to erosion only. In conclusion, the only solution that presented a protective effect against erosive wear was fluoride + stannous chloride. PGA was not capable of improving the protective effect of F in situ. (AU)

• FAPESP's process: 17/09408-3 - In situ evaluation of the anti-erosive effect of the association between sodium fluoride and propylene glycol alginate
• Grantee: Letícia Oba Sakae
• Support Opportunities: Scholarships in Brazil - Master