CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Química from Universidade dos Povos Patrice Lumumba (1973), master's at Chemistry from Universidade de São Paulo (1978) and ph.d. at Chemistry from Universidade de São Paulo (1982). Has experience in Chemistry, focusing on Inorganic Chemistry, acting on the following subjects: ruthenium, rutênio, rutenio, eletroquímica and x-ray structure. (Source: Lattes Curriculum)
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Bioinorganics, together with medicinal chemistry, has contributed to the search for new potential anticancer metallodrugs, with the development of potential therapeutic agents. In this context, many researchers have dedicated themselves to the synthesis of coordination compounds with medicinal applications, or modeling existing ones to reduce their side effects. Among those currently desc…
The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
Bioinorganic, together with medicinal chemistry, has benefited from the use of metallopharmaceuticals as drugs and therapeutic agents. In this context, several researchers have been dedicated to the synthetic chemistry of coordination compounds with medicinal application, searching for new compounds with biological activity and modeling the existing ones to reduce the their side effects. …
In the search for new coordination compounds with antitumor, and without toxicity, or with less toxicity than the platinum based-compounds, ruthenium compounds are very promising. Thus, it is necessary to evaluate the antitumor potentiality of these new compounds and try to understand the possible relationship between the intracelular localization of the compounds and their mechanism of…
The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
(Only some records are available in English at this moment)
Cancer is one of the main causes of death in the world, which is why many researchers are looking for new chemotherapy drugs and therapeutic processes. In this sense, medicinal inorganic chemistry presents itself as a good field of study. In particular, ruthenium complexes have been widely explored for the development of candidates for new anticancer metallopharmaceuticals, because of pro…
The development of metallic compounds with the aim of finding new drug candidates for the treatment of cancer is necessary, considering that this disease is a serious global public health problem. Thus, this project will be dedicated to obtaining and characterizing a series of new ruthenium(II)-nitrosyl complexes, with ligands of biological interest. In the synthesis stage, the aim is to …
(Only some records are available in English at this moment)
Cancer is one of the most deadly diseases in the world, in addition to being always growing, both in number and in diversity. Thus, in view of the need for more efficient drugs than those found on the market, and with fewer side effects than those presented by the drugs used in the treatment of the disease, the development of organic or inorganic anticancer agents, in order to find new dr…
The development of metallic compounds to find new drug candidates for the treatment of cancer has gained increasing importance in the scientific field, considering that cancer is a serious public health problem worldwide. Therefore, several metallic compounds have been studied, seeking to identify more selective and effective compounds. In particular, ruthenium-based compounds have shown …
The development of metallic compounds, in order to find new drug candidates for the treatment of cancer, has gained increasing importance in the scientific field, given that this disease is a serious worldwide public health problem . For this, several transition metals have been used, seeking to identify more selective and effective compounds, without side effects. In particular, rutheniu…
(Only some records are available in English at this moment)
The search and development of new drugs with high cytotoxicity and low side effects is urgently needed since cancer remains a leading cause of deaths worldwide. Our research group, (LERCI, UFSCar, Brazil) has been studying Ru-based compounds containing different phosphine and bioactive ligands on coordination sphere. Since we obtained promising results from Post-doctorate research (FAPESP…
Cancer is the second leading cause of death worldwide and, the forms of treatment of this disease has some limitations, by making necessary to develop new compounds that may be effective against this disease. The ruthenium complexes has been quite promising, showing metastatic properties. Therefore, in this project will be studied ruthenium complexes containing the lapachol as ligand, whi…
Cancer is predicted to be an increasingly important cause of morbidity and mortality in the next few decades. Because of therapeutic resistance and side effects, a wide range of studies are focused on the discovery of new drugs for cancer treatment. In view of this, transition metal-based compounds have been proposed as potential antitumor activity and antimestastatic behavior, in particu…
(Only some records are available in English at this moment)