CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Institute of Biosciences of Botucatu (IBB) at UNESP, in the Biochemistry discipline, and coordinator of the Laboratory of Bioassays and Cellular Dynamics (LaBIO), he holds a degree in Biology from UNESP (2005) and a Ph.D. in Biochemistry from UNICAMP (2008), with a sandwich period at the Universitair Medisch Centrum Groningen (UMCG), in the Netherlands. He stands out in the fields of Biochemistry and Cell Biology, investigating signal transduction mechanisms in mammalian cells. His main research areas include bone biology, tissue bioengineering, development of biomimetic materials, large-scale biomaterial analysis, cell-material interaction, and nanotoxicity. As coordinator of LaBIO, funded by FAPESP, he supervises undergraduate, master's, Ph.D., and postdoctoral students, contributing to the training of a new generation of scientists. He maintains international partnerships with professors from countries such as the USA, the Netherlands, Portugal, England, Ireland, India, Italy, and Canada, expanding the global impact of his research. Currently, he serves as Vice-Director of IBB-UNESP (2021-2025) and has been a CNPq Research Productivity fellow since 2013, widely recognized for his academic leadership and innovative contributions to regenerative medicine and advanced biomedical technologies. (Source: Lattes Curriculum)
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Despite appearing to be static, bone tissue is highly dynamic, with a recognized ability to reshape and regenerate throughout the life of vertebrates; the coupling between osteoblasts and osteoclasts controls this activity. In case of extensive, critically sized lesions, support material is needed to contribute to tissue repair/regeneration events, requiring the clinical use of biomateria…
With increasing concern about the life expectancy of the population, regenerative processes of bone tissue have been urgently considered by emerging countries. Currently, it is shown that the growth of blood vessels in the bone is associated with osteogenesis, and little has been explored in the elaboration of biotechnological processes on this matter. Another important point at this conj…
The mammals skeletal system contains a collection of cells, in a hierarchical manner, maintain bone formation throughout life. In this context, we know that osteogenesis is essential for bone deposition, as well as fracture healing through regenerative mechanisms; in addition, we know these processes often decrease with the progress of age, leading to bone loss and an increased incidence …
Despite appearing static, bone tissue is highly dynamic, with a recognized capacity for remodeling and regeneration throughout the lifespan of vertebrates, an activity controlled by the coupling between osteoblasts and osteoclasts. In cases of extensive and critical-sized lesions, the need for support material arises to contribute to tissue repair/regeneration events, requiring the clinic…
Bone tissue is a specialized connective tissue which provides support for the body, so when it is injured or fractured there is a need for adequate bone healing and repair, without the formation of intermediate calluses. In this sense, the use of scaffolds is intended to boost this tissue recovery or replacement more efficiently with the use of materials composed of cells expanded in vitr…
Due to the technological gain in recent years, there has been a great advance in biotechnology and with consequences in regenerative medicine by composing biomaterials for grafting injured tissues, as well as for covering metal alloys for biomedical applications looking for become better biological performance of the organic tissue through biological responses. Despite there is advanced k…
(Only some records are available in English at this moment)
One must consider the central role that the skeleton plays in the human body, following the command that other tissues and organs regulate, which indicates that, in addition to its mechanical functions, bone is an endocrine tissue, which modulates cellular activities in different fabrics. The growing understanding that bone is a paracrine and endocrine organ serves to broaden our understa…
Organ-on-a-chip (OoC) technology consists of microfluidic devices for culturing cells that resemble tissues/organs on a physiological level. This technology has shown expectation for tissue engineering, biosensors, diagnosis and therapy, drug delivery and has gained special prominence in bioengineering and biomedical engineering research. Compared to animal models and 2D cell culture mode…
The search for adequate and efficient bone repair and regeneration treatments has been growing more and more. In this context, tissue engineering works using supports composed of cells expanded in vitro with the intention of being bioreabsorbable while a new tissue is formed. Among these types of support, the hydrogel stands out, having as an example the natural polymeric materials Algina…
(Only some records are available in English at this moment)
Bone remodeling is a tightly regulated process that depends on coordinated interactions between vascular and skeletal systems. Recent findings have highlighted the role of extracellular vesicles (EVs) derived from human aortic smooth muscle cells (AoSMCs) as key modulators of osteoblast differentiation and osteocyte transition, suggesting a novel mechanism of intercellular communication l…
This project explores an innovative approach to developing 3D-shapeable biomaterials for bone tissue engineering using photocrosslinkable rotational molding. Given the essential role of bone tissue in providing structural support and protection, regeneration is often necessary regeneration after injury. Biomaterials offer promising scaffolding solutions to support and enhance this regener…
Repairing large or non-healing bone defects is challenging and often expensive. Biomimetic materials, such as collagen-nanohydroxyapatite (Coll-nHA) scaffolds, effectively promote bone repair and osteogenesis. To address larger critical-sized defects, advanced materials are necessary to enhance the interplay between angiogenesis and osteogenesis. Long non-coding RNAs, particularly lncMALA…
It is timely to consider that cardiovascular diseases make up one of the major causes of death worldwide. The central role of vascular tissue has gained attention in recent years, mainly associated with increasing of aging. Vascular calcification, previously considered a passive degenerative condition of aging, is characterized by an ectopic deposition of inorganic calcium phosphate cryst…
With the increase in life expectancy and growth of urban centers, bone regeneration has become an issue of interest, mainly because it has increased the number of elderly and young people with fractures. Although it is able to regenerate itself in small injuries, there is a necessity to improve therapies able to support the regeneration of large disorders, mainly when a scaffold is requir…
The increase in life expectancy, as well as the concentrations of urban populations, have brought serious consequences in terms of the increase in recovery time from accidents involving bone tissue. The quality of life of these patients is directly affected and the growing government and private expenditure on innovative alternatives for healing injuries are extremely necessary. Thus, new…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 4 / 3 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 25 / 21 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 7 / 7 | Completed scholarships abroad |
| 44 / 39 | All research grants and scholarships |
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