CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at FMRP-USP - Scientific Director of the Foundation for Support to Teaching, Research, and Assistance (FAEPA) of the Hospital das Clínicas of FMRP - Deputy Head of the Department of Childcare at FMRP-USP - Sub-Coordinator of the Department of Pediatric Endocrinology of the Brazilian Society of Endocrinology and Metabolism (SBEM). He holds a research productivity grant from CNPq. He has experience in medicine, with an emphasis on pediatric endocrinology and metabolism, and has worked primarily on the following topics: adrenal gland diseases, adrenocortical tumors, neuroendocrinology, hypopituitarism and growth, Cushing's syndrome, puberty, molecular genetics, and omics applied to endocrinology. He has served as advisor for scientific initiation, master's, and doctoral programs, and as a postdoctoral supervisor. Senior Editor of Endocrine Connections - Associate Editor of Archives of Endocrinology and Metabolism - Editorial Board of the Journal of the Endocrine Society. Graduated in Medicine from the Federal University of Santa Maria (1991), Master's in Child and Adolescent Health from the University of São Paulo (1997), PhD in Child and Adolescent Health from the University of São Paulo (2001), and Post-Doctorate at the University of Montreal, Canada. (Source: Lattes Curriculum)
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To elucidate the molecular pathogenesis of endocrine tumors, several studies have investigated the role of specific genes regulating the organ development, genes involved in tumorigenesis of other tissues, such as abnormalities in genes that lead to cycle progression and cell division (oncogenes) or genes that block the cell cycle (tumor suppressor genes), miRNAs, and large noncoding (lnc…
Background: To date, there is no effective adjuvant treatment for patients with advanced or recurrent adrenocortical carcinomas (ACC). A good knowledge of the molecular abnormalities involved in this process is crucial to determine molecular prognostic markers and to discover new and individualized therapeutically targets. Aim: To investigate the role of the Wnt/beta-catenin, SHH, Vitamin…
The incidence of childhood adrenocortical (ACTs) is 10 to 15 higher in Southern Brazil, and it is associated with a germline TP53 mutation (p.R337H). Beta-catenin abnormalities are frequent is adult ACTs and transcriptoma analysis suggested that the Wnt/beta-catenin pathway is activated, and it is associated with poor prognosis in these tumors. The Sonic Hedgehog (SHH) pathway is importan…
(Only some records are available in English at this moment)
Introduction: Adrenarche is characterized by an increase in androgens produced by the adrenal glands during childhood and preadolescence, resulting from the maturation of the zona reticularis and the expression of steroidogenic enzymes. Premature adrenarche (PA) occurs when clinical signs of androgenic activity, suchas acne and axillary odor, appear before age 8 in girls and under 9 in bo…
Background: Recent studies have increasingly demonstrated that adrenocortical tumorigenesis is a complex process that requires multiple molecular events and culminates in interactions between various intracellular signaling pathways. The Wnt / Beta-catenin signaling pathway regulates normal adrenal development and function and increasing clinical and scientific evidence has indicated its …
To elucidate the molecular pathogenesis of endocrine tumors, several studies have investigated the role of specific genes regulating the organ development, genes involved in tumorigenesis of other tissues, such as abnormalities in genes that lead to cycle progression and cell division (oncogenes) or genes that block the cell cycle (tumor suppressor genes), miRNAs, and large noncoding (lnc…
(Only some records are available in English at this moment)
Background and Introduction: Adrenal tumorigenesis appears to result of a combination of two or more genetic hits but little is known about this complex crosstalk. Beta-catenin mutations and other WNT pathway abnormalities are frequently found in adrenal tumors. Primary pigmented nodular adrenocortical disease (PPNAD), a rare form of bilateral micronodular adrenocortical hyperplasia, has …
| 7 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 24 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 33 / 21 | All research grants and scholarships |
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