Professor at the University of Sao Paulo (EEFE-USP). Head of the Applied Physiology and Nutrition Research Group. Head of the laboratory of assessment and conditioning in Rheumatology. Member of the Center of Lifestye Medicine (FM USP). Bachelor in Nutrition and Sports Sciences. Research interests are: effects of nutrition and exercise on chronic diseases and aging; healthy lifestyle, sports nutrition, muscle physiology; sarcopenia; clinical exercise physiology (Source: Lattes Curriculum)
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This project aims to assess, using in vivo experimental models to challenge homeostasis (acute physical exercise and Diabetes Mellitus) along with biochemical and functional markers, whether carnosine plays the following physiological roles: protection against oxygen and nitrogen reactive species and toxic by-products of the metabolism; protection against protein glycation and carbonylati…
Cumulative evidence has shown that sedentary behavior (i.e., excessive time spent while in a sitting or reclining posture) is a strong and independent factor predisposing to poor health-related outcomes and all-cause mortality in several populations. In this context, new interventions focused on reducing sedentary time could be of great therapeutic relevance. To date, however, studies ass…
Obesity is defined by excessive accumulation of body fat, usually measured and rated by measuring the height and weight of the individual. Thus, obesity can be defined as BMI and 30 kg / m2. In Brazil, we use the term morbid obesity to be defined extreme cases of obesity. Thus, Morbid obesity is defined as BMI and 40 kg / m2 or greater than 35 kg / m2 associated with significant morbiditi…
Rheumatoid Arthritis (RA) presents increased cardiovascular risk, which can be caused by cardiovascular autonomic dysfunction, namely an increase in sympathetic activity and a reduction in parasympathetic activity. Impairment in cardiovascular reflex control exerted by the peripheral chemoreceptors may contribute to autonomic dysfunction in this population, however, this has not yet been …
Survivors of severe COVID-19 are more likely to present physical deconditioning, exertion intolerance and a higher prevalence of persistent symptoms, compromising their quality of life after hospital discharge. Conversely, physical exercises are considered a non-pharmacological therapy with great potential for rehabilitation of these individuals. In this sense, the present study proposes …
The decline in bone content and/or integrity is an inherent process of aging. However, some comorbidities may exacerbate this losses. For instance, the association of Sarcopenia and Obesity (i.e. Sarcopenic Obesity) can potentiate these effects. In this regard, although caloric restriction is the standard intervention to manage body weight, it may also promote loss of bone, emphasizing th…
The Severe Acute Respiratory Syndrome induced by the new Coronavirus (SARS-CoV-2) has been declared a worldwide pandemic. Identifying common characteristics of the disease is crucial to promote a better prognosis for patients and to reduce the occurrence of medical complications, the time to medical discharge and mortality rates. Muscle mass and strength are recognized predictive measures…
Ageing is associated with significant declines in muscle mass and strength, which is termed sarcopenia. These reductions occur when rates of muscle protein breakdown are higher than muscle protein synthesis, ensuing a negative net protein balance. Protein intake is one of the most potent stimuli to increase the rate of muscle protein synthesis. In spite of that, older individuals exhibit …
The main anabolic stimuli for hypertrophy are physical exercise and dietary protein intake. Both act synergically by increasing the muscular protein synthesis (MPS) and inhibiting and/or decreasing the muscular protein degradation (MPD). This process leads to a positive protein balance that, if chronically sustained, may result in gain of muscle mass. Nonetheless, the response generated i…
(Only some records are available in English at this moment)
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by increased cardiovascular risk. This is partly due to the negative effects of sustained inflammation on vascular function. Recently, prolonged sitting time has been shown to cause further detrimental effects on vascular function in patients with RA. Therefore, it is important to verify the positive effe…
Aging is associated with a progressive loss of skeletal muscle mass, which ultimately reduces the functional capacity. Accordingly, moderate- to high-load resistance exercise (RE) (i.e., > 65% of one repetition maximum) has been well established as an effective strategy to promote muscle mass accrual in elderly. However, there is substantial inter-individual variability in resistance exer…
Carnosine is cytoplasmic dipeptide abundantly found in the skeletal muscle. Obtained from the diet, carnosine is not directly absorbed by the skeletal muscle as it is rapidly hydrolyzed into its constituent amino acids, beta-alanine and histidine. Importantly, beta-alanine availability has been demonstrated to be the rate-limiting factor for muscle carnosine synthesis. Hence, beta-alanine…
| 3 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 10 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID