Graduated in Pharmacy-biochemistry at University of São Paulo (2001), PhD in Biotechnology at University of São Paulo (2006), postdoctoral fellow at the Heart Institute, University of São Paulo (2009) and postdoctoral fellow at the Sylvester Cancer Center, University of Miami (2011). He is currently a researcher at the National Laboratory of Biosciences (LNBio / CNPEM / MCTI), coordinating the Immunotherapy Research Group, Viral Vector Core and the Monoclonal Antibodies Engineering Unit. Has experience in immunomodulation, antitumor vaccines, immunomodulatory antibodies, engineering and production of viral vectors for expression or gene silencing, construction of chimeric aptamer RNA. Develops projects in the fields of #8203;#8203;Biotechnology, virology, gene therapy and cancer immunotherapy. (Source: Lattes Curriculum)
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Triple negative breast cancer is characterized by the absence of estrogen, progesterone receptors and low production of the her-2 protein. In this way, hormonal therapies or anti-her2 targeted immunotherapy are ineffective. The available treatment is based on surgical removal, radiotherapy, chemotherapy and currently new protocols have also been explored with the use of PD1 checkpoint inh…
In the last decade, there has been a significant development of therapeutic therapies that act on the mechanisms associated to the control of immune tolerance in T cells, mediated by receptors such as CLTA-4 and PD1, also known as immune checkpoints. The use of checkpoint inhibitors revolutionized medical practice. Furthermore, another important lymphocyte immunosuppression mechanism is r…
Immunotherapy approaches have revolutionized perspectives in the treatment of human cancer. Antibodies known as checkpoint inhibitors act on receptors constitutively expressed on lymphocytes, blocking immunosuppressive mechanisms that antagonize the antitumor response. In this way, boosting lymphocyte activity and potentiation of antitumor immune vigilance is stimulated. In recognition of…
The use of new strategies for treatment of cancer, based on immunotherapy have generated surprising results. Most of these strategies are driven to favor the activity of T cells, which are recognized to play an important role in the control and elimination of tumor cells. T cells have surface receptors that transduce signaling mediators of the activation state. The first activation signal…
(Only some records are available in English at this moment)
Breast cancer is the most common malignant neoplasm in women worldwide and one of the leading causes of death for women in developed countries. The main treatment strategy is chemotherapy followed by radiotherapy, but resistance is frequent, resulting in a 46% rate of metastasis, 25% recurrence after surgery and 75% mortality. The use of monoclonal antibodies to inhibit immune checkpoints…
Cancer is a multifactorial disease, in which cells acquire mutations, that may lead to proliferative advantages that allow their establishment and escape from the immune system. The therapeutic strategies developed for the treatment of cancer are based on surgery, radiotherapy, chemotherapy, and immunotherapy. Immunotherapy has revolutionized clinical oncology, enabling the treatment of i…
Previos data of our group show the possibility to engineer immunomodulator VLPs with the capacity to potentialize antitumor imumne response. These VLPs derive from retroviral capsides and are encrusted with anchored proteins in the particle surface. We observed that VLPs containing the CD40 ligand, CD40L, activate presenting cells and potencialize the antitumoral immune reponse in animals…
(Only some records are available in English at this moment)
The development of new therapeutic approaches for the treatment of cancer is based on the use of models for evaluation and confirmation of the biological effect. Cell culture assays can provide proofs of concept that warrant testing in more complex biological systems, such as using animal models. In the field of cancer immunotherapy, where the aim is to potentiate cells of the immune syst…
Cancer is a disease in which cells acquire genetic alterations. The tumor may have characteristics that promote its growth, such as the escape of the immune system. This ability to evade the immunity is largely attributed to the existence of immunosuppressive mechanisms that regulate the balance between immunotolerance and immunovigilance, in order to avoid an autoimmune response of T cel…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 12 / 5 | Completed scholarships in Brazil |
| 25 / 16 | All research grants and scholarships |
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CV Lattes
ORCID