Marcio Chaim Bajgelman
CV Lattes
GoogleMyCitations
ORCID
Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy-biochemistry at University of São Paulo (2001), PhD in Biotechnology at University of São Paulo (2006), postdoctoral fellow at the Heart Institute, University of São Paulo (2009) and postdoctoral fellow at the Sylvester Cancer Center, University of Miami (2011). He is currently a researcher at the National Laboratory of Biosciences (LNBio / CNPEM / MCTIC), coordinating the Imunotherapy Research Group, Viral Vector Core and the Monoclonal Antibodies Engineering Unit. Has experience in immunomodulation, antitumor vaccines, immunomodulatory antibodies, engineering and production of viral vectors for expression or gene silencing, construction of chimeric aptamer RNA. Develops projects in the fields of ​​Biotechnology, virology, gene therapy and cancer immunotherapy. (Source: Lattes Curriculum)
- Engineering t cells harboring new transgenic TCRs isolated from tumor infiltrated lymphocytes in animals undergone therapeutic protocols using immunomodulators, AP.R
Abstract
The use of new strategies for treatment of cancer, based on immunotherapy have generated surprising results. Most of these strategies are driven to favor the activity of T cells, which are recognized to play an important role in the control and elimination of tumor cells. T cells have surface receptors that transduce signaling mediators of the activation state. The first activation sign...
- Development of strategies for antitumor immunomodulation, AP.R
Abstract
Here we propose a new platform for antitumor immunotherapy based on the use of nanoparticles. These particles are engineered to interact with specific receptors on target cells in order to drive the tropism. In this proposal we plan to explore new nanoparticle formulations harboring different ligands to evaluate tropism selectivity and immunomodulatory properties. We also propose to gen...
- Exploration of molecular targets to inhibit regulatory T cells and potentiate antitumoral immunity, AP.R
Abstract
Regulatory T cells (Treg) have the unique property of suppressing the proliferation of effector T cells, promoting immunological tolerance. Clinical samples isolated from patients revealed that the infiltrate of Tregs in the tumoral site correlates with the progression of cancer. Literature data suggest that elimination of Treg cells may act in synergy with other anticancer therapies. ...
- Development of chimeric aptamers for inactivation of human regulatory T cells, BP.IC
Abstract
Cancer is a disease in which cells acquire genetic alterations. The tumor may have characteristics that promote its growth, such as the escape of the immune system. This ability to evade the immunity is largely attributed to the existence of immunosuppressive mechanisms that regulate the balance between immunotolerance and immunovigilance, in order to avoid an autoimmune response of T c...
- Engineering targeted multifunctional nanoparticles with antitumor activity, BP.DR
Abstract
In this project, we present a new antitumor approach based on the development of biological nanoparticles derived from extracellular vesicles. These vesicles will be functionalized with ligands, targeting cancer cells, strengthen the activation of dendritic cells and inducing cytotoxicity at the tumor site. We are planning to generate immunomodulatory vesicles functionalized with a liga...
- Development of a FoxP3 transcriptional silencing strategy to inactivate regulatory T cells and potentiate antitumor immunity, BP.DD
Abstract
Clinical samples isolated from patients revealed that the infiltrate of regulatory T cells (Tregs) in the tumor site correlates with the progression of cancer. Data from literature suggests that elimination of Treg cells may act in synergy with other anticancer therapies. Among the most popular strategies, regulatory T cells can be inactivated by depletion, using antibodies or toxins di...
- Development of a strategy to inhibit Regulatory T cells, based on blocking the traffic of Regulatory T cells by RNAi, to potentiate antitumoral response, BP.MS
Abstract
Regulatory T cells (Tregs) have the unique property to inhibit the proliferation of T lymphocytes and play an important role in maintaining immunologic tolerance. The analysis of clinical samples isolated from tumoral sites reveals the infiltration of Treg cells and shows that the tumoral progression is correlated with the infiltrate. The traffic of regulatory T cells to tumoral sites i...
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 9 / 2 | Completed scholarships in Brazil |
| 14 / 7 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 5 |
| Citations | 17 |
| Cit./Article | 3.4 |
| Data from Web of Science | |
BAJGELMAN, MARCIO C.; DOS SANTOS, LEONARDO; SILVA, GUSTAVO J. J.; NAKAMUTA, JULIANA; SIRVENTE, RAQUEL A.; CHAVES, MARCIO; KRIEGER, JOSE EDUARDO; STRAUSS, BRYAN E.. Preservation of cardiac function in left ventricle cardiac hypertrophy using an AAV vector which provides VEGF-A expression in response to p53. VIROLOGY, v. 476, p. 106-114, FEB 2015. Web of Science Citations: 10.
BAJGELMAN, MARCIO C.; MEDRANO, RUAN F. V.; CARVALHO, ANNA CAROLINA P. V.; STRAUSS, BRYAN E.. AAVPG: A vigilant vector where transgene expression is induced by p53. VIROLOGY, v. 447, n. 1-2, p. 166-171, DEC 2013. Web of Science Citations: 5. (10/03958-2)
MANRIQUE-RINCON, ANDREA J.; BERALDO, CAMILA M.; TOSCARO, JESSICA M.; BAJGELMAN, MARCIO C.. Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. FRONTIERS IN IMMUNOLOGY, v. 8, SEP 19 2017. Web of Science Citations: 1. (12/13132-0, 13/02041-6, 15/01488-2)
MANRIQUE-RINCON, ANDREA J.; DE CARVALHO, ANNA C.; EUGENIA RIBEIRO DE CAMARGO, M.; FRANCHINI, KLEBER G.; BAJGELMAN, MARCIO C.. Development of a flow cytometry assay which allows to evaluate the efficiency of immunomodulatory vaccines to enhance T cell-mediated antitumor response. Journal of Biotechnology, v. 284, p. 11-16, OCT 20 2018. Web of Science Citations: 1. (17/06692-2, 13/02041-6)
LOIOLA, LIVIA M. D.; BATISTA, MARINA; CAPELETTI, LARISSA B.; MONDO, GABRIELA B.; ROSA, RHUBIA S. M.; MARQUES, RAFAEL E.; BAJGELMAN, MARCIO C.; CARDOSO, MATEUS B.. Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles. Journal of Colloid and Interface Science, v. 553, p. 540-548, OCT 1 2019. Web of Science Citations: 0. (17/01167-7, 15/25406-5, 16/21598-0, 17/09203-2, 17/06692-2, 16/16905-0)