Abstract
Portion of the Institutional Technical Reserve for Research Infrastructure Costs - Exercise 2024. (AU)
Universidade Estadual de Campinas (UNICAMP). Centro de Hematologia e Hemoterapia (HEMOCENTRO) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a degree in Medicine from the Faculty of Medicine of Jundiaí (1979), a specialization in Medicine from the University of São Paulo (1983), a Master's degree in Internal Medicine from the State University of Campinas (1987), and a PhD in Internal Medicine from the State University of Campinas (1989). Completed postdoctoral training at Elizabeth Hospital of Boston, Tufts University (1991), Beth Israel Hospital, Harvard University (1992), and the Laboratoire de Thérapie Génique, Hôpital St. Louis-Paris, INSERM (1999). Currently, she is a Full Professor in the Hematology Department at the State University of Campinas.She began her career researching the clinical and molecular aspects of chronic anemias, including hereditary anemias such as sickle cell disease, pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, spherocytosis, and elliptocytosis, among others; as well as acquired anemias such as myelodysplastic syndromes, deficiency anemias, and aplastic anemia.Over the past 20 years, she has also investigated the relationship between normal or leukemic hematopoietic stem cells and the bone marrow niche in both animal models and humans. She is the author of more than 400 scientific articles published in specialized journals.She plays a major role in the training of human resources, with the vast majority of her former students being successful researchers in Brazil and the United States. She has supervised over 200 students, including those at the masters and doctoral levels, undergraduate researchers, postdoctoral fellows, medical residents, and newly graduated trainees.In recognition of her work, she has received several national and international awards, including the SCOPUS Award in 2010 and the National Order of Scientific Merit in 2018. She also works in the diagnosis and treatment of patients with anemia, especially those with hereditary diseases, and serves on technical committees of the São Paulo State Department of Health and the Ministry of Health. She has been an elected member of the Brazilian Academy of Sciences (ABC) since 2010. (Source: Lattes Curriculum)
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Portion of the Institutional Technical Reserve for Research Infrastructure Costs - Exercise 2024. (AU)
PORTION OF RESERVE FOR TECHNICAL INFRASTRUCTURE COSTS INSTITUCIONAL SEARCH - YEAR 2022. (AU)
PORTION OF THE INSTITUTIONAL TECHNICAL RESERVE FOR INFRASTRUCTURE COSTS FOR RESEARCH - EXERCISE 2023. (AU)
Application of the portion for institutional infrastructure costs for the acquisition of air conditioners (permanent material). (AU)
PORTION OF RESERVE FOR TECHNICAL INFRASTRUCTURE COSTS INSTITUCIONAL SEARCH - YEAR 2019 (AU)
(Only some records are available in English at this moment)
Somatic mutations in genes responsible for epigenetic modulation seem to occur years before the diagnosis of acute myeloid leukemia (AML). Recently, the role of ascorbic acid (vitamin C) in regulating the activity of TET2 (ten-eleven-translocation 2), an important enzyme that catalyzes the hydroxylation of 5-methylcytosine, whose gene is frequently mutated in aging and myeloid neoplasms, …
Traditional Chinese Medicine (TCM) has been garnering increasing interest from conventional science. Artemisia annua, a key component of TCM, contains artemisinin, which has significant therapeutic applications, especially in the treatment of malaria. Artesunate, derived from artemisinin, has been studied for its diverse therapeutic properties, including anti-inflammatory, antidiabetic, a…
(Only some records are available in English at this moment)
Myelodysplastic syndrome (MDS) is a bone marrow disease that affects the production of blood cells, with a risk of developing into acute myeloid leukemia. Treatment options are limited, highlighting the need for alternative therapies. Compounds derived from green tea, such as (-)-epigallocatechin-3-gallate (EGCG), have shown therapeutic potential in leukemia models. However, their effect …
The bone marrow tumor microenvironment plays an essential role in the progression of leukemic cells. The reciprocal interaction between neoplastic, stromal, and endothelial cells, as well as the interaction of these cells with components of the extracellular matrix and soluble factors creates an environment that drives tumor development and progression, in addition to affecting the respon…
(Only some records are available in English at this moment)
Acute Myeloid Leukemia (AML) corresponds to a hematological neoplasm that includes the abnormal and disordered proliferation of immature blood and bone marrow (BM) cells quite common in people over 65 years of age. BM transplantation is considered the only curative treatment for AML; however, it is not applicable to most patients due to age and the presence of comorbidities. In addition, …
2 / 2 | Ongoing grants |
34 / 21 | Completed research grants |
4 / 4 | Ongoing scholarships in Brazil |
99 / 46 | Completed scholarships in Brazil |
2 / 1 | Completed scholarships abroad |
141 / 74 | All research grants and scholarships |
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