Abstract
Somatic mutations in genes responsible for epigenetic modulation appear to occur years before the diagnosis of acute myeloid leukemia (AML). The role of ascorbic acid (vitamin C) in regulating the activity of TET2 (ten-eleven translocation 2) has recently been described. TET2 is an important enzyme that catalyzes the hydroxylation of 5-methylcytosine: the TET2 gene is frequently mutated d…