Helio Vannucchi

• Abstract

  Epigenetics involves mechanisms that are essential for the proper embryonic development of mammals, and changes at this stage may lead to various metabolic disorders, such as obesity. This disease is characterized by chronic inflammation of low grade, which leads to numerous diseases that seriously compromise the health of the individual, in addition to having a multifactorial origin invo…

  Methylation and gene expression patterns of inflammation and energetic metabolism in offspring of rats subjected to folic acid supplemented diet, AP.R

• Abstract

  Folic acid participates in several metabolic pathways including controlling homocysteine synthesis and degradation and provides methyl groups for methylation reactions particularly those associated with the epigenetic regulation. Because presenting this activity folic acid can influence significantly the degree of reprogramming gene methylation during embryonic period and it may lead to t…

  Methylation and expression patterns of miRNA and cardiovascular disease and type 2 diabetes mellitus genes in the offspring of rats dams submitted to acid folic deficient and supplemented diets, AP.R

• Abstract

  Analgesics are the main cause accidents from toxic agents exposure. Acetaminophen (APAP, 4-hidroxiacetanilida) presents analgesic and antipyretic properties, despite being safe in therapeutic doses, in cases of overdose promotes hepatic necrosis in humans and animals. The APAP is bioactivated by cytochrome P450 in a highly reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) th…

  Histoenzimatic, genomic and proteomic analysis of Artepillin C in liver toxicity induced by acetaminophen, AP.R

(Only some records are available in English at this moment)

• Abstract

  Currently obesity is a serious public health problem worldwide and has a multifactorial origin involving both environmental and genetic factors. There are some genes that are involved with obesity such as the gene for Pro-Opiomelanocortin (POMC). The objective of this research project is to investigate the patterns of expression and methylation of the POMC gene in the offspring of rats su…

  Methylation and expression patterns of the POMC gene in the offspring of rats subjected to diets deficient and supplemented with folic acid, BP.MS

• Abstract

  Folic acid participates in several metabolic pathways including controlling the homocysteine synthesis and degradation and it provides methyl groups for methylation reactions especially those associated with the control of the integrity and epigenetic regulation of the genome. By presenting this activity folic acid can influence significantly the degree of gene methylation during the embr…

  Methylation and expression patterns of miRNA and cardiovascular disease and type 2 diabetes mellitus genes in the offspring of rats dams submitted to acid folic deficient and supplemented diets, BP.PD

• Abstract

  Analgesics are the main cause accidents from toxic agents exposure. Acetaminophen (APAP, 4-hidroxiacetanilida) presents analgesic and antipyretic properties, despite being safe in therapeutic doses, in cases of overdose promotes hepatic necrosis in humans and animals. The APAP is bioactivated by cytochrome P450 in a highly reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) th…

  Effects of Artepillin C in acute liver toxicity induced by Acetaminophen, BP.DR

(Only some records are available in English at this moment)