CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Medicina from Universidade de São Paulo (1971) and doctorate at Physiology from Universidade de São Paulo (1978). Has experience in Physiology, focusing on Neorofisiology, acting on the following subjects: melatonina, melatonin, pineal, ritmo circadiano and ritmos biologicos. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| A connection between sleep and hunger |
| Una conexión entre el sueño y el hambre |
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| News published in Agência FAPESP Newsletter about the researcher |
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Using a new conceptual framework of analysis of melatonin physiology and pathophysiology, the aim of this project is to study the Hypomelatoninemia Syndrome, either primary or secondary. The project is divided in three groups of research. The first group aims to study the consequences of the absence and therapeutic replacement of melatonin onseveral aspects of pregnancy physiology and fet…
The study aims to study disturbances among children and teenagers that could be related to maternal shiftwork exposure during pregnancy. Animal models have shown that skiftwork have a negative impact on programming (structure, metabolism and physiology) of vital organs in the fetus generating a permanent harm. A possible explanation has been proposed to be related to light exposure at nig…
Through a interdisciplinary multicentric research group, approaching the scientific object from three scientific levels (basic, clinical and epidemiological) and using the endocrinological and the chronobiological paradigms of analysis the aim of the pres (AU)
The aim of this work is to study the role played by the hormone melatonin in the control of energy metabolism. In particular, the role played by the central nervous system action of melatonin and the timing effect of melatonin signal regulating either the central master oscillator or the peripheral oscillators located in the metabolic active tissues. Using in vivo and in vitro experiments…
(Only some records are available in English at this moment)
Energy metabolism is organized to deal with the body's needs and their variations over 24 hours. Melatonin, which is elevated at night, is synthesized by the pineal gland and acts to synchronize physiological functions, including energy metabolism. In the fetus, although the fetal pineal gland produces melatonin, its rhythm is determined by the mother's production of pineal melatonin, thi…
Energy metabolism is organized to deal with the needs of the body and its variations over a 24-hour period. The circulating melatonin, which is elevated at night, is synthesized by the pineal gland and acts to synchronize physiological functions, including energy metabolism. Among its functions, it is known that melatonin has action on insulin and glucose uptake; insulin is potentiated by…
According to the World Health Organization (WHO), cancer is the second leading cause of death in the world. The development of new therapies and the discovery of new molecules capable of fighting cancer are major targets of the 21st century research. Melatonin is at the center of several studies against cancer and has been unveiled as a potent oncotic molecule, acting from the beginning o…
(Only some records are available in English at this moment)
Many hormones and neurotransmitters regulate feeding behavior. Leptin is in the spotlight since mutations in the genes encoding this hormone or its receptor resulted in severe obesity. Melatonin (Mel) is involved in the regulation of energy balance and its administration reduces food intake, body weight and abdominal fat in rodent models. In vitro, rhythmic Mel treatment synchronizes lept…
Maternal melatonin plays a pivotal role in providing photoperiodic information to the fetus and by that influencing the regulation and timing of internal rhythms of the offspring and their preparation for extrauterine life. Maternal melatonin deprivation (mainly caused by nightwork and shift work) during pregnancy and lactation has negative health consequences for the offspring that conti…
Melatonin is a hormone produced by the pineal gland during the night. As your circulatory rhythms are robust and predictable they are strong synchronizers for the expression of several physiological processes, including energy metabolism. Studies in our group have shown that melatonin replacement orally in older animals, regulates insulin responses, reduces food intake due to body weight …
| 1 / 1 | Ongoing research grants |
| 11 / 7 | Completed research grants |
| 25 / 17 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 40 / 28 | All research grants and scholarships |
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