Melatonin and the control of energy metabolism: central and peripheral actions and the circadian timing of the metabolic function

• Grant number: 09/52920-0
• Support Opportunities: Research Projects - Thematic Grants
• Duration: January 01, 2010 - March 31, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: José Cipolla Neto
• Grantee: José Cipolla Neto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Fabio Bessa Lima
• Associated scholarship(s): 11/15462-4 - Effects of treatment with insulin and melatonin on body temperature and activity/rest rhythms in diabetic rats, BP.MS; 11/04359-8 - Role of noradrenergic synchronized on melatonin synthesis of pineal gland culture: functionals characteristics and action mechanisms, BP.MS; 11/05884-9 - Retinal melatonin synthesis in streptozotocin-induced diabetic Wistar rats: AANAT regulation study, BP.PD; 10/12947-4 - Effects of central melatonin replacement therapy in older animals - changes in insulin signal transmission in the hypothalamus, liver, muscle and adipose tissue., BP.DR; 07/07790-6 - Role of insulin on the regulation of melatonin synthesis by pineal gland: action mechanisms and functional characteristics, BP.PD

Abstract

The aim of this work is to study the role played by the hormone melatonin in the control of energy metabolism. In particular, the role played by the central nervous system action of melatonin and the timing effect of melatonin signal regulating either the central master oscillator or the peripheral oscillators located in the metabolic active tissues. Using in vivo and in vitro experiments, in healthy or diabetic animals, in intact or pinealectomized, young or old animals, treated or not with melatonin, is our intention to study the metabolic function and gene expression in the central nervous system, white adipose tissue, skeletal muscle and the liver. On the other hand, is our aim to study the other side of the system, looking at the effects of the neuro-humoral signals linked to the several states of the metabolic function on the cellular and molecular processes involved in melatonin synthesis by the pineal gland. In addition, in collaboration with the Radiology Institute of Hospital of Clinics of the Faculty of Medicine, University of São Paulo, we intend to perform some clinical investigation trying to correlate the functional state of the pineal gland to alterations of the functional magnetic ressonance or positron emission tomography (PET) and SPECT images in healthy subjects and patients with diseases that might involve melatonin disfunction in their pathogenesis. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PELICIARI-GARCIA, RODRIGO ANTONIO; ANDRADE-SILVA, JESSICA; CIPOLLA-NETO, JOSE; DE OLIVEIRA CARVALHO, CARLA ROBERTA. Leptin Modulates Norepinephrine-Mediated Melatonin Synthesis in Cultured Rat Pineal Gland. BIOMED RESEARCH INTERNATIONAL, 2013. (11/04359-8, 09/52920-0)

RAMOS-LOBO, ANGELA M.; BUONFIGLIO, DANIELLA C.; CIPOLLA-NETO, JOSE. Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats. DIABETOLOGY & METABOLIC SYNDROME, v. 7, APR 29 2015. (09/52920-0)

MENDES, CAROLINE; DE SOUZA LOPES, ANA MARIA; DO AMARAL, FERNANDA GASPAR; PELICIARI-GARCIA, RODRIGO A.; TURATI, ARIANE DE OLIVEIRA; HIRABARA, SANDRO M.; SCIALFA FALCAO, JULIETA H.; CIPOLLA-NETO, JOSE. Adaptations of the aging animal to exercise: role of daily supplementation with melatonin. Journal of Pineal Research, v. 55, n. 3, p. 229-239, OCT 2013. (09/52920-0)

CANTERAS, NEWTON S.; RIBEIRO-BARBOSA, ERIKA RENATA; GOTO, MARINA; CIPOLLA-NETO, JOSE; SWANSON, LARRY W.. The Retinohypothalamic tract: Comparison of axonal projection patterns from four major targets. BRAIN RESEARCH REVIEWS, v. 65, n. 2, p. 150-183, JAN 1 2011. (09/52920-0)

PELICIARI-GARCIA, RODRIGO A.; ZANQUETTA, MELISSA M.; ANDRADE-SILVA, JESSICA; GOMES, DAYANE A.; BARRETO-CHAVES, MARIA LUIZA; CIPOLLA-NETO, JOSE. Expression of Circadian Clock and Melatonin Receptors within Cultured Rat Cardiomyocytes. CHRONOBIOLOGY INTERNATIONAL, v. 28, n. 1, p. 21-30, 2011. (09/52920-0)

AMARAL, FERNANDA G.; TURATI, ARIANE O.; BARONE, MARK; SCIALFA, JULIETA H.; BUONFIGLIO, DANIELLA DO CARMO; PERES, RAFAEL; PELICIARI-GARCIA, RODRIGO A.; AFECHE, SOLANGE C.; LIMA, LARISSA; SCAVONE, CRISTOFORO; et al. Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia. Journal of Pineal Research, v. 57, n. 1, p. 67-79, AUG 2014. (04/06767-2, 08/11026-2, 09/52920-0)

PELICIARI-GARCIA, RODRIGO ANTONIO; ANDRADE-SILVA, JESSICA; CIPOLLA-NETO, JOSE; DE OLIVEIRA CARVALHO, CARLA ROBERTA. Leptin Modulates Norepinephrine-Mediated Melatonin Synthesis in Cultured Rat Pineal Gland. BIOMED RESEARCH INTERNATIONAL, v. 2013, p. 8-pg., 2013-01-01. (09/52920-0, 11/04359-8)

BUONFIGLIO, DANIELLA DO CARMO; PELICIARI-GARCIA, RODRIGO ANTONIO; DO AMARAL, FERNANDA GASPAR; PERES, RAFAEL; ARAUJO NOGUEIRA, TATIANE C.; AFECHE, SOLANGE CASTRO; CIPOLLA-NETO, JOSE. Early-Stage Retinal Melatonin Synthesis Impairment in Streptozotocin-Induced Diabetic Wistar Rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 52, n. 10, p. 7416-7422, SEP 2011. (04/06767-2, 09/52920-0)

HALPERN, BRUNO; MANCINI, MARCIO C.; BUENO, CLARISSA; BARCELOS, ISABELLA P.; DE MELO, MARIA EDNA; LIMA, MARCOS S.; CARNEIRO, CAMILA G.; SAPIENZA, MARCELO T.; BUCHPIGUEL, CARLOS ALBERTO; DO AMARAL, FERNANDA GASPAR; et al. Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: A Proof-of-Concept Study. Diabetes, v. 68, n. 5, p. 947-952, MAY 1 2019. (09/52920-0)

ANDRADE-SILVA, JESSICA; CIPOLLA-NETO, JOSE; PELICIARI-GARCIA, RODRIGO A.. The in vitro maintenance of clock genes expression within the rat pineal gland under standard and norepinephrine-synchronized stimulation. NEUROSCIENCE RESEARCH, v. 81-82, p. 1-10, APR-MAY 2014. (11/04359-8, 07/07790-6, 09/52920-0)