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Melatonin and the control of energy metabolism: central and peripheral actions and the circadian timing of the metabolic function

Abstract

The aim of this work is to study the role played by the hormone melatonin in the control of energy metabolism. In particular, the role played by the central nervous system action of melatonin and the timing effect of melatonin signal regulating either the central master oscillator or the peripheral oscillators located in the metabolic active tissues. Using in vivo and in vitro experiments, in healthy or diabetic animals, in intact or pinealectomized, young or old animals, treated or not with melatonin, is our intention to study the metabolic function and gene expression in the central nervous system, white adipose tissue, skeletal muscle and the liver. On the other hand, is our aim to study the other side of the system, looking at the effects of the neuro-humoral signals linked to the several states of the metabolic function on the cellular and molecular processes involved in melatonin synthesis by the pineal gland. In addition, in collaboration with the Radiology Institute of Hospital of Clinics of the Faculty of Medicine, University of São Paulo, we intend to perform some clinical investigation trying to correlate the functional state of the pineal gland to alterations of the functional magnetic ressonance or positron emission tomography (PET) and SPECT images in healthy subjects and patients with diseases that might involve melatonin disfunction in their pathogenesis. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Falta de melatonina causa obesidade e diabetes, aponta pesquisa 
Research shows lack of melatonin causes obesity and diabetes 
La falta de melatonina provoca obesidad y diabetes, apunta una investigación 
Articles published in Pesquisa FAPESP Magazine about the research grant:
A connection between sleep and hunger 
Una conexión entre el sueño y el hambre 

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HALPERN, BRUNO; MANCINI, MARCIO C.; BUENO, CLARISSA; BARCELOS, ISABELLA P.; DE MELO, MARIA EDNA; LIMA, MARCOS S.; CARNEIRO, CAMILA G.; SAPIENZA, MARCELO T.; BUCHPIGUEL, CARLOS ALBERTO; DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE. Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: A Proof-of-Concept Study. Diabetes, v. 68, n. 5, p. 947-952, MAY 1 2019. Web of Science Citations: 3.
RAMOS-LOBO, ANGELA M.; BUONFIGLIO, DANIELLA C.; CIPOLLA-NETO, JOSE. Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats. DIABETOLOGY & METABOLIC SYNDROME, v. 7, APR 29 2015. Web of Science Citations: 5.
AMARAL, FERNANDA G.; TURATI, ARIANE O.; BARONE, MARK; SCIALFA, JULIETA H.; BUONFIGLIO, DANIELLA DO CARMO; PERES, RAFAEL; PELICIARI-GARCIA, RODRIGO A.; AFECHE, SOLANGE C.; LIMA, LARISSA; SCAVONE, CRISTOFORO; BORDIN, SILVANA; REITER, RUSSEL J.; MENNA-BARRETO, LUIZ; CIPOLLA-NETO, JOSE. Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia. Journal of Pineal Research, v. 57, n. 1, p. 67-79, AUG 2014. Web of Science Citations: 26.
ANDRADE-SILVA, JESSICA; CIPOLLA-NETO, JOSE; PELICIARI-GARCIA, RODRIGO A. The in vitro maintenance of clock genes expression within the rat pineal gland under standard and norepinephrine-synchronized stimulation. NEUROSCIENCE RESEARCH, v. 81-82, p. 1-10, APR-MAY 2014. Web of Science Citations: 5.
MENDES, CAROLINE; DE SOUZA LOPES, ANA MARIA; DO AMARAL, FERNANDA GASPAR; PELICIARI-GARCIA, RODRIGO A.; TURATI, ARIANE DE OLIVEIRA; HIRABARA, SANDRO M.; SCIALFA FALCAO, JULIETA H.; CIPOLLA-NETO, JOSE. Adaptations of the aging animal to exercise: role of daily supplementation with melatonin. Journal of Pineal Research, v. 55, n. 3, p. 229-239, OCT 2013. Web of Science Citations: 20.
PELICIARI-GARCIA, RODRIGO ANTONIO; ANDRADE-SILVA, JESSICA; CIPOLLA-NETO, JOSE; DE OLIVEIRA CARVALHO, CARLA ROBERTA. Leptin Modulates Norepinephrine-Mediated Melatonin Synthesis in Cultured Rat Pineal Gland. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 5.
BUONFIGLIO, DANIELLA DO CARMO; PELICIARI-GARCIA, RODRIGO ANTONIO; DO AMARAL, FERNANDA GASPAR; PERES, RAFAEL; ARAUJO NOGUEIRA, TATIANE C.; AFECHE, SOLANGE CASTRO; CIPOLLA-NETO, JOSE. Early-Stage Retinal Melatonin Synthesis Impairment in Streptozotocin-Induced Diabetic Wistar Rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 52, n. 10, p. 7416-7422, SEP 2011. Web of Science Citations: 27.
CANTERAS, NEWTON S.; RIBEIRO-BARBOSA, ERIKA RENATA; GOTO, MARINA; CIPOLLA-NETO, JOSE; SWANSON, LARRY W. The Retinohypothalamic tract: Comparison of axonal projection patterns from four major targets. BRAIN RESEARCH REVIEWS, v. 65, n. 2, p. 150-183, JAN 1 2011. Web of Science Citations: 32.
PELICIARI-GARCIA, RODRIGO A.; ZANQUETTA, MELISSA M.; ANDRADE-SILVA, JESSICA; GOMES, DAYANE A.; BARRETO-CHAVES, MARIA LUIZA; CIPOLLA-NETO, JOSE. Expression of Circadian Clock and Melatonin Receptors within Cultured Rat Cardiomyocytes. CHRONOBIOLOGY INTERNATIONAL, v. 28, n. 1, p. 21-30, 2011. Web of Science Citations: 19.

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