CV Lattes
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Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Rui Curi is a Bachelor in Pharmacy and Biochemistry from the State University of Maringá (1980), a Master (1982), and a Ph.D. (1984) in Human Physiology at the Institute of Biomedical Sciences, University of São Paulo. Rui Curi was a full professor at the Department of Physiology and Biophysics, Institute of Biomedical Sciences, Universidade de São Paulo. He works on intermediary metabolism and the metabolism and function of leukocytes. He investigates the metabolism of glutamine and fatty acids and their control by insulin, diets, and physical exercise. He supervised 25 master's degree dissertations, 53 doctoral theses, and 17 post-doctors. Rui Curi was head of the Department, Director of ICB-USP, and Undergraduate Studies Provost Adviser. He was an Adjunct Distinguished Research Fellow of the School of Biomedical Science, Faculty of Health Sciences, Curtin University (Australia). He was a recipient of the Comenda of the Pharmacy Federal Council and Fellow of the Guggenheim Foundation (USA). He received recognition from Curtin University as an Excellent and Active Visiting Fellow and Honoris Causa Doctor from the Maringá State University. He is a member of Sao Paulo Sciences Academy and the Brazilian Academy of Sciences. Rui Curi has 47234 citations, an H Index 105, (Google Scholar, 26.11.2025). He is currently director of Escola Superior do Instituto Butantan (ESIB), and Professor of Postgraduate Studies at Universidade Cruzeiro do Sul and Universidade de Marília (UNIMAR). 1A CNPq researcher. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Well-regulated insulin and glucose |
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Metabolic disorders, stress, and psychological disturbances (stress, depression, anxiety, and suicidal behavior) in workers involved in public security negatively impact the quality of life, increase public health expenditures, and affect the efficiency and quality of services performed to society. The incidence of death from cardiovascular and liver diseases in the Military Police of the…
Musculoskeletal disorders are frequent in diabetic patients and are associated with an imbalance between protein synthesis and degradation and impaired satellite cell activity. Despite this, the extensor digitorum longus (EDL) and soleus muscles of diabetic rats, when induced to hypertrophy by compensatory surgery, show mass muscle gain of the same magnitude as the control. Type 2 diabete…
Breast cancer is the leading cause of cancer mortality among women worldwide and is the type of cancer with the highest incidence worldwide, a fact that also occurs in Latin American countries in economic transition such as Chile and Brazil. In relation to the therapeutic options, depending on the stage of the cancer, cell subtype and size of the tumor, the treatment of choice is decided.…
(Only some records are available in English at this moment)
Researchers in New Zealand conduct experiments in humans, investigating postexercise muscle inflammation and beetroot juice supplementation. For these analyses, muscle biopsy is performed and inflammatory markers are evaluated by gene expression after an isokinetic dynamometer contraction session and correlated with force recovery up to 48 hours after exercise. Brazilian researchers have …
Peripheral Insulin Resistance (IR) and inflammation follow the development of Type 2 Diabetes Mellitus (DM2), with a high prevalence in obese patients. However, a significant percentage of non-obese individuals present DM2, especially in specific regions. For example, in Brazil, this percentage reaches 10 to 20%, while, in Japan, about 60% of type 2 diabetic patients have no Obesity. The …
The diabetic state undertakes the function of skeletal muscle myopathy and causes reduction in skeletal muscle mass. Strength training is prescribed as part of treatment of diabetes mellitus (DM) because it improves glycemic control and promote increased muscle mass. Recently, we observed that compensatory hypertrophy of the soleus and long digital extensor (EDL) due to functional overloa…
(Only some records are available in English at this moment)
Diabetes mellitus (DM) is one of the predominant comorbidities among non-surviving COVID-19 patients. Diabetic patients exhibit a reduced immunogenic response to vaccines for infectious diseases in general. In Brazil, over 75% of type 2 diabetics are overweight or obese. Obesity itself affects the body's response to vaccines. The Butantan Institute produces two COVID-19 vaccines, the wide…
Low grade chronic inflammation accompanies the onset of installation of insulin resistance (IR), hyperglycaemia and type 2 diabetes mellitus (DM2), and it is associated with neuropathy, nephropathy, and difficulties in healing, comorbidities of this disease. Despite these facts, the inflammatory profile of bone marrow cells (where leukocytes are produced and released into the bloodstream)…
Musculoskeletal disorders are frequent in diabetic patients and are associated with an imbalance between protein synthesis and degradation and impaired satellite cell activity. Despite this, the extensor digitorum longus (EDL) and soleus muscles of diabetic rats, when induced to hypertrophy by compensatory surgery, show mass muscle gain of the same magnitude as the control. Type 2 diabete…
(Only some records are available in English at this moment)
Diabetes mellitus is one of the predominant comorbidities among non-surviving COVID-19 patients. Diabetic patients have a lower immunogenic response to vaccines for infectious diseases in general. In Brazil, more than 75% of type 2 diabetics are overweight or obese. The presence of obesity alone affects the body's responses to vaccines, but little is known about the impairment generated e…
The activities to be carried out by the scholarship holder are part of Mariana Cruz Lazzarin's postdoctoral project entitled "Immunogenicity of COVID-19 vaccines used in Brazil in type 1 and type 2 diabetes mellitus with or without obesity," whose objective is to investigate differences in the immunogenicity of COVID-19 vaccines in different experimental models of diabetes mellitus. The i…
Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and hyperglycemia. Although obesity is the main factor in the development of T2DM, a considerable proportion of patients are not obese. The Goto-Kakizaki (GK) rat is a model of T2DM and develops peripheral insulin resistance, hyperglycemia and chronic inflammation spontaneously, without obesity. Results from…
(Only some records are available in English at this moment)
Professor Keith A. Sharkey is one of the most globally recognized scientists in intestinal microbiota research. During the BEPE, Gabriela will carry out experiment on the relevance of intestinal microbiota in the diabetic phenotype of Goto-Kakizaki (GK) rats. The GK rat develops type 2 diabetes mellitus (T2DM) spontaneously, without obesity. T2DM causes marked changes in enteric nervous …
Reduced glucose uptake in muscle cell triggered by insulin signalling impairment due to insulin receptor nitrosylation is a mechanism that contributes to the development of metabolic syndrome. Phenolic compounds from fruits and vegetables are likely to prevent metabolic syndrome through activation of AMPK, a protein that induces insulin-independent glucose uptake and inhibits inducible ni…
The epigenetic mechanisms are modulated by environmental factors that can alter the individual phenotype. One explanation for the increase in obesity may be associated with changes in these mechanisms. Experimental studies in animals and clinical trials in humans show changes in DNA methylation resulting from obesity. In addition to the beneficial effects on lipid profile, fish oil is rec…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing grants |
| 48 / 23 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 74 / 29 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 136 / 66 | All research grants and scholarships |
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