CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Rui Curi is Bachelor in Pharmacy and Biochemistry from the State University of Maringá (1980), a Master (1982), and a Ph.D. (1984) in Human Physiology at the Institute of Biomedical Sciences, University of São Paulo. Rui Curi was a full professor at the Department of Physiology and Biophysics, Institute of Biomedical Sciences, Universidade de São Paulo. He works on intermediary metabolism and metabolism and function of leukocytes. He investigates glutamine and fatty acids' metabolism and the control by insulin, diets, and physical exercise. He supervised 25 master's degree dissertations, 53 doctoral theses, and 17 post-doctors. Rui Curi was head of the Department, Director of ICB-USP, and Undergraduate Studies Provost Adviser. He was an Adjunct Distinguished Research Fellow of the School of Biomedical Science, Faculty of Health Sciences, Curtin University (Australia). He was a recipient of the Comenda of the Pharmacy Federal Council and Fellow of Guggenheim Foundation (USA). He received recognition from Curtin University as an Excellent and Active Visiting Fellow and Honoris Causa Doctor from the Maringá State University. One of the 100,000 Most Influential Scientists, according to PLOS One 2020. TOP 6,000 scientists of the world according to the AD Scientific Index 2022. He is a member of Sao Paulo Sciences Academy and the Brazilian Academy of Sciences. Rui Curi has 38,451 citations, H Index 96, and i10 Index 534 (Google Scholar, 19.03.2023). He is currently Director of the Nucleus of Production of Immunobiologicals of the Bioindustrial Center of the Butantan Institute, and Full Professor of the Interdisciplinary Postgraduate Program in Health Sciences (Medicine I) at the Cruzeiro do Sul University. (Source: Lattes Curriculum)
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| Well-regulated insulin and glucose |
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Breast cancer is the leading cause of cancer mortality among women worldwide and is the type of cancer with the highest incidence worldwide, a fact that also occurs in Latin American countries in economic transition such as Chile and Brazil. In relation to the therapeutic options, depending on the stage of the cancer, cell subtype and size of the tumor, the treatment of choice is decided.…
Instituto Butantan (IB), has always worked to answer public health challenges and has a long tradition in the development and manufacturing of vaccines and antibodies. This project addresses both areas, influenza vaccines and human monoclonal antibodies, focusing on critical targets that demand attention and require the use of strategies based on solid scientific, clinical, regulatory and…
Peripheral insulin resistance (IR) and inflammation follow the development of type 2 diabetes mellitus (DM2), with a high prevalence in obese patients. However, a significant percentage of non-obese individuals present DM2, especially in specific regions. For example, in Brazil, this percentage reaches 10 to 20%, while, in Japan, about 60% of type 2 diabetic patients have no obesity. The …
Researchers in New Zealand conduct experiments in humans, investigating postexercise muscle inflammation and beetroot juice supplementation. For these analyses, muscle biopsy is performed and inflammatory markers are evaluated by gene expression after an isokinetic dynamometer contraction session and correlated with force recovery up to 48 hours after exercise. Brazilian researchers have …
Peripheral Insulin Resistance (IR) and inflammation follow the development of Type 2 Diabetes Mellitus (DM2), with a high prevalence in obese patients. However, a significant percentage of non-obese individuals present DM2, especially in specific regions. For example, in Brazil, this percentage reaches 10 to 20%, while, in Japan, about 60% of type 2 diabetic patients have no Obesity. The …
The diabetic state undertakes the function of skeletal muscle myopathy and causes reduction in skeletal muscle mass. Strength training is prescribed as part of treatment of diabetes mellitus (DM) because it improves glycemic control and promote increased muscle mass. Recently, we observed that compensatory hypertrophy of the soleus and long digital extensor (EDL) due to functional overloa…
(Only some records are available in English at this moment)
Diabetes mellitus is one of the predominant comorbidities among non-surviving COVID-19 patients. Diabetic patients have a lower immunogenic response to vaccines for infectious diseases in general. In Brazil, more than 75% of type 2 diabetics are overweight or obese. The presence of obesity alone affects the body's responses to vaccines, but little is known about the impairment generated e…
Low grade chronic inflammation accompanies the onset of installation of insulin resistance (IR), hyperglycaemia and type 2 diabetes mellitus (DM2), and it is associated with neuropathy, nephropathy, and difficulties in healing, comorbidities of this disease. Despite these facts, the inflammatory profile of bone marrow cells (where leukocytes are produced and released into the bloodstream)…
Musculoskeletal disorders are frequent in diabetic patients and are associated with an imbalance between protein synthesis and degradation and impaired satellite cell activity. Despite this, the extensor digitorum longus (EDL) and soleus muscles of diabetic rats, when induced to hypertrophy by compensatory surgery, show mass muscle gain of the same magnitude as the control. Type 2 diabete…
The activities to be carried out by the scholarship holder are part of Mariana Cruz Lazzarin's postdoctoral project entitled "Immunogenicity of COVID-19 vaccines used in Brazil in type 1 and type 2 diabetes mellitus with or without obesity," whose objective is to investigate differences in the immunogenicity of COVID-19 vaccines in different experimental models of diabetes mellitus. The i…
Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and hyperglycemia. Although obesity is the main factor in the development of T2DM, a considerable proportion of patients are not obese. The Goto-Kakizaki (GK) rat is a model of T2DM and develops peripheral insulin resistance, hyperglycemia and chronic inflammation spontaneously, without obesity. Results from…
Type 2 diabetes mellitus (DM2) patients exhibit peripheral insulin resistance, usually triggered by excess body mass. However, about 15% of DM2 diabetic patients are not obese, and in Japan, it reaches 60%, a condition reproduced in Goto-Kakizaki (GK) rats. These animals spontaneously exhibit insulin resistance in early life. Musculoskeletal disorders are highly prevalent in diabetic pati…
(Only some records are available in English at this moment)
Professor Keith A. Sharkey is one of the most globally recognized scientists in intestinal microbiota research. During the BEPE, Gabriela will carry out experiment on the relevance of intestinal microbiota in the diabetic phenotype of Goto-Kakizaki (GK) rats. The GK rat develops type 2 diabetes mellitus (T2DM) spontaneously, without obesity. T2DM causes marked changes in enteric nervous …
Reduced glucose uptake in muscle cell triggered by insulin signalling impairment due to insulin receptor nitrosylation is a mechanism that contributes to the development of metabolic syndrome. Phenolic compounds from fruits and vegetables are likely to prevent metabolic syndrome through activation of AMPK, a protein that induces insulin-independent glucose uptake and inhibits inducible ni…
The epigenetic mechanisms are modulated by environmental factors that can alter the individual phenotype. One explanation for the increase in obesity may be associated with changes in these mechanisms. Experimental studies in animals and clinical trials in humans show changes in DNA methylation resulting from obesity. In addition to the beneficial effects on lipid profile, fish oil is rec…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 48 / 23 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 74 / 29 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 132 / 62 | All research grants and scholarships |
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