CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Faculty of Pharmaceutical Sciences at USP, specializing in the interaction between bioactive lipids and medications in cardiovascular health. Her research focuses on omega-3 fatty acids, trans-resveratrol, and plant sterols, using advanced techniques in chromatography coupled with mass spectrometry and multivariate statistical analysis. She collaborates with researchers from renowned national and international institutions (United States, France, Spain, and Italy), conducting preclinical and clinical trials. She coordinates the public campaign CorAção, aimed at preventing cardiovascular diseases. (Source: Lattes Curriculum)
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The RTI - 2025 Annual Resource Enforcement Plan, drawn up from meetings with teachers and unit managementsought consensus on the priority projects with a broad effect on the research developed by the teaching community of FCF. The result of this work was presented and approved at the ordinary session of theCongregation held on May 15, 2025. (AU)
The RTI - 2024 Annual Resource Enforcement Plan, drawn up from meetings with teachers and unit managementsought consensus on the priority projects with a broad effect on the research developed by the teaching community of FCF. The result of this work was presented and approved at the ordinary session of the Congregation held on xxxx xx, 2024. (AU)
Cardiovascular diseases (CVDs) are the leading cause of global mortality, despite significant advances in prevention and treatment. Atherosclerosis, a chronic inflammatory condition, underlies ischemic events such as infarction and stroke, triggered by the instability and rupture of plaques. Current guidelines recommend drugs primarily aimed at reducing Low-Density-Lipoprotein cholesterol…
(Only some records are available in English at this moment)
Studies have shown that beyond the onset symptoms of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection, excessive coagulation, cytokine storm, leukopenia, lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill patients. Taking into account that there are still no approved drugs or vaccines, the potential effect of dietary supplements to …
Cardiovascular disease is the leading cause of mortality in many countries. Atherosclerosis is a chronic inflammation of the arteries that underlies the ischemic events involved in the myocardium infarction and stroke. Although important advances had been developed in terms of Atherosclerosis prevention, more recent strategies have focused on plaque regression or stability. The atheroscl…
The consumption of lipids containing higher amount of saturated or trans-fatty acids has been associated to the higher risk for cardiovascular diseases, while mono or polyunsaturated fatty acids have showed cardiovascular protection. Among the polyunsaturated fatty acids (PUFA), n-6 FA are associated to a more pro-inflammatory condition, caused by eicosanoids produced from the enzymatic o…
(Only some records are available in English at this moment)
The consumption of omega-3 fatty acids (n-3 FAs), particularly eicosapentaenoic acid (EPA; C20:5) and docosahexaenoic acid (DHA; C22:6), is widely recommended for their ability to reduce cardiovascular residual risk, with marine oils being the primary source for such supplementation. However, marine oils present several limitations, including the presence of cholesterol, high cost, potent…
Cardiovascular diseases (CVDs) are the leading cause of global mortality, despite significant advances in prevention and treatment. Atherosclerosis, a chronic inflammatory condition, underlies ischemic events such as infarction and stroke, triggered by the instability and rupture of plaques. Current guidelines recommend drugs primarily aimed at reducing Low-Density-Lipoprotein cholesterol…
Fatty acids play a crucial role in various metabolic pathways, with their proportions and distributions across different cells and tissues influenced by diet and metabolism. In addition to providing energy through oxidative reactions, fatty acids serve as substrates for the synthesis of numerous molecules involved in cellular signaling processes. Therefore, quantifying fatty acids in biol…
The ingestion of omega-3 fatty acids (n-3 FA), mainly eicosapentaenoic acid (EPA; C20:5) and docosahexaenoic acid (DHA; C22:6), has been associated with the prevention of cardiovascular diseases. Except for genetically modified plants, vegetable oils do not contain EPA or DHA. But, they can be biosynthesized from ±-linolenic acid (ALA; C18:3 n-3) and stearidonic acid (SDA; C18:4 n-3), wit…
Despite pharmacological advances, cardiovascular diseases (CVD) have been the leading cause of mortality in the world. Most recommendations for CVD prevention includes the consumption of omega 3 fatty acids (n-3 FA), because of the capacity of these fatty acids to reduce inflammation and triacylglycerol concentrations, controlling the atherosclerosis progression and CVD risks. However, n-…
Cardiovascular diseases (CVD) are the leading cause of mortality in the world. Despite the advances achieved in the pharmacological and surgical aspects, little progress has been obtained towards prevention. Among the alternatives to reduce CVD risk, the intake of omega 3 fatty acids (n3FA) supplements, in especial the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has shown …
(Only some records are available in English at this moment)
Addition of antioxidants is one main strategy to hamper oxidation in oil-in-water (O/W) emulsions. Among the factors governing antioxidant efficacy, polarity was found to play a key role, with nonpolar antioxidants working better in O/W emulsions than polar ones, as stated by the Polar Paradox. In this context, phenolic compounds are recognized as potent antioxidants, but due to their hig…
In recent years, immunotherapy has gained great attention. The principle of empowering a patient's immune system to perform its natural role - to fight disease - has yet to be applied to reversing atherosclerosis and its clinical manifestations. Plaque regression as a result of LDL cholesterol lowering is very limited and the residual risk of cardiovascular events after treatment with sta…
The consumption of lipids containing a higher amount of saturated or trans-fatty acids has been associated with higher risk for cardiovascular diseases. For this reason, the World Health Organization (WHO) recommends the intake of polyunsaturated fatty acids (PUFAs) as a healthier source of lipids. However, PUFAs are very susceptible to oxidative degradation. This chemical reaction can pr…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 34 / 25 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 32 / 25 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 77 / 61 | All research grants and scholarships |
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