CV Lattes
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ORCID
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Biochemistry and Pharmacy from Universidade Estadual de Londrina (1987) and doctorate at Biochemistry from Universidade Federal de São Paulo (1997). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: endooligopeptidase, endopeptidase, bradykinin-potentianting peptides(BPPs) and oligopeptidases. (Source: Lattes Curriculum)
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Toxins from animal venom are a material of great scientific interest, mainly due to their possible use for therapeutic purposes, which includes their use as drugs and/or as structural model for the development of drugs with therapeutic potential for the treatment of human diseases, in addition to their possible application as tools for biotechnological purposes. Crotamine, which is one of…
Mental disorders (MDs) are a group of potentially serious and highly prevalent diseases affecting the Central Nervous System (CNS). Studies that seek biochemical/molecular and/or cellular alterations could help in the diagnosis accuracy, as well as for the better understanding of the neurobiology involved in the MDs, thus allowing the possible identification of potential new targets for t…
The National Institute of Translational Medicine (NITM) was created in 2008 with the purpose of establishing a national network of research centers with outstanding experience in the investigation of biomarkers and new therapeutic targets and molecules in neuropsychiatric disorders, acting in the strategic area of Health and Medicines defined by the Federal Government. In the base of all …
Venom toxins are of great scientific interest, mainly due to their possible use for therapeutic purposes, i.e., as pharmaceuticals and/or as structural models for the development of drugs that may be employed for the treatment of human and/or for biotechnological applications. Crotamine, which is one of the most abundant toxins of the rattlesnake venom, is capable of penetrating cells, as…
Venom toxins are of utmost scientific interest, not only for the studies of the pathophysiological pathways underlying the envenomation processes, but also mainly because of their possible use for therapeutic purposes, i.e. as drug and/or as structural template model for drug development that could be employed for the treatment of human diseases.Considering the biochemical and structural …
Schizophrenia and bipolar disorder (BD) are neurodevelopmental illnesses that cause an enormous burden of suffering, high morbidity and mortality rates. Only preventive strategies that include promotion of mental health, identification of risk factors across the life cycle, and appropriate early interventions may reduce these rates. This project focuses in primary, secondary, and tertiary…
(Only some records are available in English at this moment)
The etiology of Depression is complex, and its development is dependent on both genetic and ambient factors. Depression is considered one of the most debilitating mental diseases and actually, and more than 200 million individuals around the world are affected. However, its pathophysiology is still not fully understood, as well as there are no biomarkers to support the diagnosis. Also, th…
Mental Disorders (MDs) are characterized by alterations in the functioning of the CNS, and these psychiatric conditions have attracted the attention of researchers from diverse areas due to the high prevalence and the highly debilitating clinical characteristics. Unlike most of the known organic diseases, the diagnosis for MDs still essentially based on clinical interviews, which can ofte…
Crotamine was first described in the 1970s, and was characterized mainly by its characteristic hind limb immobilization of rodents, observed only in the case of high dose administration. Recently, our group described other pharmacological and therapeutically useful effects regarding the use of reduced doses of crotamine, including cytotoxic effect with preference for proliferatively activ…
Crotamine have been studied for some time and different biological activities were presented, although little is known about the molecular mechanism of action involved in its myotoxic effect, which was the first to be described and is characterized by the immobilization of the skeletal muscle of rodents. We have recently demonstrated that this effect involves the action of crotamine on so…
The various biological activities presented by crotamine have been studied for a long time, although little is known about the mechanism(s) involved in molecular action(s) of your myotoxic effect, which is characterized by skeletal muscle immobilization when injected into rodents and which stimulated their identification and characterization in rattlesnake venom. Initially it was suggeste…
(Only some records are available in English at this moment)
Schizophrenia (SCZ) is a severe chronic mental disease. The current body of evidence suggests that it is a multifactorial disease with genetic and environmental factors, leading to an altered neurodevelopment. Ndel1 (nuclear-distribution element-like 1) is an oligopeptidade that binds to Disrupted-in-Schizophrenia 1 (DISC1) gene product, which has been largely studied as a SCZ vulnerabili…
| 3 / 3 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 8 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 29 / 19 | All research grants and scholarships |
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