CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Biochemistry and Pharmacy from Universidade Estadual de Londrina (1987) and doctorate at Biochemistry from Universidade Federal de São Paulo (1997). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: endooligopeptidase, endopeptidase, bradykinin-potentianting peptides(BPPs) and oligopeptidases. (Source: Lattes Curriculum)
Mental disorders (MDs) are a group of potentially serious and highly prevalent diseases affecting the Central Nervous System (CNS). Studies that seek biochemical/molecular and/or cellular alterations could help in the diagnosis accuracy, as well as for the better understanding of the neurobiology involved in the MDs, thus allowing the possible identification of potential new targets for t…
The National Institute of Translational Medicine (NITM) was created in 2008 with the purpose of establishing a national network of research centers with outstanding experience in the investigation of biomarkers and new therapeutic targets and molecules in neuropsychiatric disorders, acting in the strategic area of Health and Medicines defined by the Federal Government. In the base of all …
Venom toxins are of great scientific interest, mainly due to their possible use for therapeutic purposes, i.e., as pharmaceuticals and/or as structural models for the development of drugs that may be employed for the treatment of human and/or for biotechnological applications. Crotamine, which is one of the most abundant toxins of the rattlesnake venom, is capable of penetrating cells, as…
Venom toxins are of utmost scientific interest, not only for the studies of the pathophysiological pathways underlying the envenomation processes, but also mainly because of their possible use for therapeutic purposes, i.e. as drug and/or as structural template model for drug development that could be employed for the treatment of human diseases.Considering the biochemical and structural …
Schizophrenia and bipolar disorder (BD) are neurodevelopmental illnesses that cause an enormous burden of suffering, high morbidity and mortality rates. Only preventive strategies that include promotion of mental health, identification of risk factors across the life cycle, and appropriate early interventions may reduce these rates. This project focuses in primary, secondary, and tertiary…
(Only some records are available in English at this moment)
Mental Disorders (MDs) are characterized by alterations in the functioning of the CNS, and these psychiatric conditions have attracted the attention of researchers from diverse areas due to the high prevalence and the highly debilitating clinical characteristics. Unlike most of the known organic diseases, the diagnosis for MDs still essentially based on clinical interviews, which can ofte…
Crotamine was first described in the 1970s, and was characterized mainly by its characteristic hind limb immobilization of rodents, observed only in the case of high dose administration. Recently, our group described other pharmacological and therapeutically useful effects regarding the use of reduced doses of crotamine, including cytotoxic effect with preference for proliferatively activ…
Crotamine have been studied for some time and different biological activities were presented, although little is known about the molecular mechanism of action involved in its myotoxic effect, which was the first to be described and is characterized by the immobilization of the skeletal muscle of rodents. We have recently demonstrated that this effect involves the action of crotamine on so…
The various biological activities presented by crotamine have been studied for a long time, although little is known about the mechanism(s) involved in molecular action(s) of your myotoxic effect, which is characterized by skeletal muscle immobilization when injected into rodents and which stimulated their identification and characterization in rattlesnake venom. Initially it was suggeste…
(Only some records are available in English at this moment)
Schizophrenia (SCZ) is a severe chronic mental disease. The current body of evidence suggests that it is a multifactorial disease with genetic and environmental factors, leading to an altered neurodevelopment. Ndel1 (nuclear-distribution element-like 1) is an oligopeptidade that binds to Disrupted-in-Schizophrenia 1 (DISC1) gene product, which has been largely studied as a SCZ vulnerabili…
| 2 / 2 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 27 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 21 |
| Citations | 74 |
| Cit./Article | 3.5 |
| Data from Web of Science | |
PORTA, LUCAS C.; CAMPEIRO, JOANA D.; PAPA, GIOVANNA B.; OLIVEIRA, EDUARDO B.; GODINHO, ROSELY O.; RODRIGUES, TIAGO; HAYASHI, MIRIAN A. F.. In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine. Toxicon, v. 185, p. 64-71, OCT 15 2020. Web of Science Citations: 0. (13/13392-4, 18/03102-2, 17/02413-1, 18/00014-5, 18/21381-6)
DE CARVALHO PORTA, LUCAS; FADEL, VALMIR; D'ARC CAMPEIRO, JOANA; OLIVEIRA, EDUARDO BRANDT; GODINHO, ROSELY OLIVEIRA; HAYASHI, MIRIAN AKEMI FURUIE. Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 98, n. 11, SEP 2020. Web of Science Citations: 0. (14/50891-1, 17/02413-1, 18/20014-0, 18/21381-6)
NANI, JOAO V.; LEE, RICHARD S.; YONAMINE, CAMILA M.; SANT'ANNA, OSVALDO A.; JULIANO, MARIA A.; GADELHA, ARY; MARI, JAIR J.; HAYASHI, MIRIAN A. F.. Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics. SCIENTIFIC REPORTS, v. 10, n. 1, OCT 28 2020. Web of Science Citations: 0. (19/09207-3, 17/02413-1, 12/50191-4, 13/13392-4)
MONTE, GABRIELA GUILHERME; NANI, V, JOAO; DE ALMEIDA CAMPOS, MARINA ROSSETO; DAL MAS, CAROLINE; NEGRI MARINS, LUCAS AUGUSTO; MARTINS, LUCAS GELAIN; TASIC, LJUBICA; MORI, MARCELO A.; HAYASHI, MIRIAN A. F.. Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 92, p. 19-30, JUN 8 2019. Web of Science Citations: 0. (14/50867-3, 15/07019-4, 13/13392-4, 17/02413-1, 18/06510-4)
CAMPEIRO, JOANA D.; MARINOVIC, MARCELO P.; CARAPETO, FERNANDO CINTRA; DAL MAS, CAROLINE; MONTE, GABRIELA GUILHERME; PORTA, LUCAS CARVALHO; NERING, MARCELA B.; OLIVEIRA, EDUARDO B.; HAYASHI, MIRIAN A. F.. Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profile. Amino Acids, v. 50, n. 2, p. 267-278, FEB 2018. Web of Science Citations: 3. (15/08812-0, 17/02413-1, 13/13392-4)
CAMPEIRO, JOANA DARC; DAM, WENDY; MONTE, GABRIELA GUILHERME; PORTAL, LUCAS CARVALHO; GONCALVES DE OLIVEIRA, LILIAN CAROLINE; NERING, MARCELA BEGO; VIANA, GUSTAVO MONTEIRO; CARAPETOS, FERNANDO CINTRA; OLIVEIRA, EDUARDO BRANDT; VAN DEN BORN, JACOB; et al. Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo. SCIENTIFIC REPORTS, v. 9, MAR 1 2019. Web of Science Citations: 0. (13/13392-4, 17/02413-1)
MARINOVIC, MARCELO P.; CAMPEIRO, JOANA D.; LIMA, SUNAMITA C.; ROCHA, ANDREA L.; NERING, MARCELA B.; OLIVEIRA, EDUARDO B.; MORI, MARCELO A.; HAYASHI, MIRIAN A. F.. Crotamine induces browning of adipose tissue and increases energy expenditure in mice. SCIENTIFIC REPORTS, v. 8, MAR 22 2018. Web of Science Citations: 1. (13/13392-4, 17/02413-1)
DAL MAS, CAROLINE; ROSSATO, LUANA; SHIMIZU, THAIS; OLIVEIRA, EDUARDO B.; DA SILVA JUNIOR, I, PEDRO; MEIS, JACQUES F.; COLOMBO, ARNALDO LOPES; HAYASHI, MIRIAN A. F.. Effects of the Natural Peptide Crotamine from a South American Rattlesnake on Candida auris, an Emergent Multidrug Antifungal Resistant Human Pathogen. BIOMOLECULES, v. 9, n. 6, JUN 2019. Web of Science Citations: 1. (13/13392-4, 17/02413-1)
GADELHA, A.; VENDRAMINI, A. M.; YONAMINE, C. M.; NERING, M.; BERBERIAN, A.; SUIAMA, M. A.; OLIVEIRA, V.; LIMA-LANDMAN, M. T.; BREEN, G.; BRESSAN, R. A.; et al. Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia. TRANSLATIONAL PSYCHIATRY, v. 5, DEC 8 2015. Web of Science Citations: 11. (13/13392-4, 11/50740-5)
GADELHA, ARY; YONAMINE, CAMILA M.; OTA, VANESSA K.; OLIVEIRA, VITOR; SATO, JOAO RICARDO; BELANGERO, SINTIA I.; BRESSAN, RODRIGO A.; HAYASHI, MIRIAN A. F.. ACE I/D genotype-related increase in ACE plasma activity is a better predictor for schizophrenia diagnosis than the genotype alone. SCHIZOPHRENIA RESEARCH, v. 164, n. 1-3, p. 109-114, MAY 2015. Web of Science Citations: 11. (12/08941-6)
GADELHA, ARY; MACHADO, MAURICIO F. M.; YONAMINE, CAMILA M.; SATO, JOAO R.; JULIANO, MARIA A.; OLIVEIRA, VITOR; BRESSAN, RODRIGO A.; HAYASHI, MIRIAN A. F.. Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia - A potential biomarker?. JOURNAL OF PSYCHIATRIC RESEARCH, v. 47, n. 5, p. 657-663, MAY 2013. Web of Science Citations: 16. (09/17726-9, 10/01394-4, 11/50740-5)
RODRIGUEZ, BENJAMIN; NANI, JOAO VICTOR; ALMEIDA, PRISCILA G. C.; BRIETZKE, ELISA; LEE, RICHARD S.; HAYASHI, MIRIAN A. F.. Neuropeptides and oligopeptidases in schizophrenia. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 108, p. 679-693, JAN 2020. Web of Science Citations: 0. (14/50867-3, 14/50891-1, 17/02413-1, 14/18938-8, 19/09207-3)
NANI, V, JOAO; FONSECA, MATHEUS C.; ENGI, SHEILA A.; PERILLO, MAYARA G.; DIAS, CARLOS S. B.; GAZARINI, MARCOS L.; KORTH, CARSTEN; CRUZ, FABIO C.; HAYASHI, MIRIAN A. F.. Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. JOURNAL OF PSYCHOPHARMACOLOGY, v. 34, n. 4, JAN 2020. Web of Science Citations: 0. (14/50891-1, 18/20014-0, 17/02413-1, 19/09207-3)
DAL MAS, C.; PINHEIRO, D. A.; CAMPEIRO, J. D.; MATTEI, B.; OLIVEIRA, V.; OLIVEIRA, E. B.; MIRANDA, A.; PEREZ, K. R.; HAYASHI, M. A. F.. Biophysical and biological properties of small linear peptides derived from crotamine, a cationic antimicrobial/antitumoral toxin with cell penetrating and cargo delivery abilities. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1859, n. 12, p. 2340-2349, DEC 2017. Web of Science Citations: 4. (13/13392-4, 17/02413-1)
DAL MAS, CAROLINE; NANI, JOAO V.; NOTO, CRISTIANO; YONAMINE, CAMILA M.; DA CUNHA, GRACCIELLE RODRIGUES; MANSUR, RODRIGO B.; OTA, VANESSA K.; BELANGERO, SINTIA IOLE; CORDEIRO, QUIRINO; KAPCZINSKI, FLAVIO; et al. Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia. SCHIZOPHRENIA RESEARCH, v. 208, p. 202-208, JUN 2019. Web of Science Citations: 2. (13/13392-4, 12/08941-6, 11/50740-5)
TASIC, LJUBICA; PONTES, JOAO G. M.; CARVALHO, MICHELLE S.; CRUZ, GUILHERME; DAL MAS, CAROLINES; SETHI, SUMIT; PEDRINI, MARIANA; RIZZO, LUCAS B.; ZENI-GRAIFF, MAIARA; ASEVEDO, ELSON; et al. Metabolomics and lipidomics analyses by H-1 nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis. SCHIZOPHRENIA RESEARCH, v. 185, p. 182-189, JUL 2017. Web of Science Citations: 7. (13/13392-4, 14/18938-8)
GADELHA, ARY; YONAMINE, CAMILA M.; NERING, MARCELA; RIZZO, LUCAS BORTOLOTTO; NOTO, CRISTIANO; COGO-MOREIRA, HUGO; TEIXEIRA, ANTONIO LUCIO; BRESSAN, RODRIGO; MAES, MICHAEL; BRIETZKE, ELISA; et al. Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia. PSYCHIATRY RESEARCH, v. 229, n. 3, p. 702-707, OCT 30 2015. Web of Science Citations: 9. (13/13392-4, 09/17726-9, 11/50740-5)
KARPEL, RICHARD L.; LIBERATO, MICHELLE DA SILVA; CAMPEIRO, JOANA D.; BERGEON, LORNA; SZYCHOWSKI, BRIAN; BUTLER, ANDREW; MARINO, GIOVANNI; CUSIC, JOELLE F.; GONCALVES DE OLIVEIRA, LILIAN CAROLINE; OLIVEIRA, EDUARDO B.; et al. Design and characterization of crotamine-functionalized gold nanoparticles. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 163, p. 1-8, MAR 1 2018. Web of Science Citations: 3. (15/24018-1, 17/02413-1, 13/13392-4)
GADELHA, ARY; COLEMAN, JONATHAN; BREEN, GEROME; MAZZOTI, DIEGO ROBLES; YONAMINE, CAMILA M.; PELLEGRINO, RENATA; OTA, VANESSA KIYOMI; BELANGERO, SINTIA IOLE; GLESSNER, JOSEPH; SLEIMAN, PATRICK; et al. Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity. SCHIZOPHRENIA RESEARCH, v. 172, n. 1-3, p. 60-67, APR 2016. Web of Science Citations: 4. (13/13392-4, 12/08941-6, 11/50740-5)
LIMA, SUNAMITA DE CARVALHO; PORTA, LUCAS DE CARVALHO; LIMA, ALVARO DA COSTA; CAMPEIRO, JOANA D'ARC; MEURER, YWLLIANE; TEIXEIRA, NATHALIA BERNARDES; DUARTE, THIAGO; OLIVEIRA, EDUARDO BRANDT; PICOLO, GISELE; GODINHO, ROSELY OLIVEIRA; et al. Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles. PLoS Neglected Tropical Diseases, v. 12, n. 8, AUG 2018. Web of Science Citations: 2. (13/13392-4, 17/02413-1, 15/07019-4)
NANI, V, JOAO; DAL MAS, CAROLINE; YONAMINE, CAMILA M.; OTA, VANESSA K.; NOTO, CRISTIANO; BELANGERO, I, SINTIA; MARI, JAIR J.; BRESSAN, RODRIGO; CORDEIRO, QUIRINO; GADELHA, ARY; et al. A Study in First-Episode Psychosis Patients: Does Angiotensin I-Converting Enzyme Activity Associated With Genotype Predict Symptom Severity Reductions After Treatment With Atypical Antipsychotic Risperidone?. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 23, n. 11, p. 721-730, NOV 2020. Web of Science Citations: 0. (19/09207-3, 12/08941-6, 17/02413-1, 17/25016-8)
USO DA CROTAMINA PARA A MODULAÇÃO DO METABOLISMO E CONTROLE DE GANHO DE PESO ANIMAL BR1020170009777 - Universidade Federal de São Paulo (UNIFESP). Mirian Akemi Furuie Hayashi; Joana D´Arc Campeiro; Marcelo Paradiso Marinovic; Marcelo Alves Da Silva Mori - January 2017, 17
ISOLATION AND PURIFICATION PROCEDURE OF VASOPEPTIDASE PEPTIDE INHIBITORS CA2440749 - Antonio Carlos Martins de Camargo; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antônio Carlos Martins de Camargo; Fernanda Calheta Vieira Portaro; Alessandra Ferragini Murback; Danielle Alves Ianzer; Sandra Helena Poliselli Farsky; Mario Sergio Palma; Mirian Akemi Furuie Hayashi - March 2002, 18
HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA) CA2507811 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antonio Carlos Martins de Camargo; Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Juliano Rodrigo Guerreiro - December 2003, 08
HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA) DE2003636265 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antonio Carlos Martins de Camargo; Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Juliano Rodrigo Guerreiro - December 2003, 08
ISOLATION AND PURIFICATION PROCEDURE OF VASOPEPTIDASE PEPTIDE INHIBITORS EP20020704503 - Antonio Carlos Martins de Camargo; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antônio Carlos Martins de Camargo; Fernanda Calheta Vieira Portaro; Alessandra Ferragini Murback; Danielle Alves Ianzer; Sandra Helena Poliselli Farsky; Mario Sergio Palma; Mirian Akemi Furuie Hayashi - March 2002, 18
HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA) EP20030812536 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antonio Carlos Martins de Camargo; Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Juliano Rodrigo Guerreiro - December 2003, 08
USE OF CROTAMINE, KIT AND COMPOSITION EP20060721611 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Tetsuo Yamane; Irina Kerkis; Alexandre Kerkis; Gandhi Rádis Baptista; Mirian Akemi Furuie Hayashi; Katsuhiro Konno; Álvaro Rossan de Brandão Prieto da Silva; Lygia da Veiga Pereira; Eduardo Brandt de Oliveira - March 2006, 17
ISOLATION AND PURIFICATION PROCEDURE OF VASOPEPTIDASE PEPTIDE INHIBITORS PCT/BR2002/000041 - Antonio Carlos Martins de Camargo; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antônio Carlos Martins de Camargo; Fernanda Calheta Vieira Portaro; Alessandra Ferragini Murback; Danielle Alves Ianzer; Sandra Helena Poliselli Farsky; Mario Sergio Palma; Mirian Akemi Furuie Hayashi - March 2002, 18
HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA) PCT/BR2003/000189 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antonio Carlos Martins de Camargo; Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Juliano Rodrigo Guerreiro - December 2003, 08
USE OF CROTAMINE, KIT AND COMPOSITION PCT/BR2006/000052 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Tetsuo Yamane; Irina Kerkis; Alexandre Kerkis; Gandhi Rádis Baptista; Mirian Akemi Furuie Hayashi; Katsuhiro Konno; Álvaro Rossan de Brandão Prieto da Silva; Lygia da Veiga Pereira; Eduardo Brandt de Oliveira - March 2006, 17
PROCESSO PARA A DETERMINAÇÃO DA ESTRUTURA PRIMÁRIA DO RNA MENSAGEIRO CODIFICANTE PARA A ENDOOLIGOPEPTIDASE A HUMANA (HEOPA) [GENBANK ACC NºAF217798] E DA SUA SEQÜÊNCIA PROTÉICA [GENBANK ACC Nº AAF24516], PARA A DETERMINAÇÃO DO GENE DA EOPA HUMANA, E PARA A PRODUÇÃO DA EOPA HUMANA RECOMBINANTE; PROCESSO DE GERAÇÃO DE ANTICORPOS ANTI-HEOPA; PROCESSO DE PADRONIZAÇÃO E UTILIZAÇÃO DE SUBSTRATOS SINTÉTICOS PARA A DETERMINAÇÃO DAS PROPRIEDADES BIOQUÍMICAS E PROTEOLÍTICAS DA HEOPA; PROCESSO DE IDENTIFICAÇÃO E PRODUÇÃO DE INIBIDORES DA EOPA, OBTENÇÃO DE ANTICORPOS COM ATIVIDADE INIBITÓRIA SOBRE A ATIVIDADE CATALÍTICA E SOBRE A INTERAÇÃO COM OLIGOPEPTÍDEOS; MÉTODO DE IDENTIFICAÇÃO DESSA PROTEÍNA EM PATOLOGIAS CONGÊNITAS, INFECCIOSAS E DEGENERATIVAS DO SISTEMA NERVOSO CENTRAL, E MÉTODO DE DETERMINAÇÃO DO PAPEL DA EOPA EM PROCESSOS IMUNOLÓGICOS; MÉTODO DE DIAGNÓSTICO IMUNO-QUÍMICO E/OU ENZIMÁTICO, PARA A PREVENÇÃO, EVOLUÇÃO DE PATOLOGIAS, PROGNÓSTICO OU TRATAMENTO DE DOENÇAS CONGÊNITAS, INFECCIOSAS E DEGENERATIVAS DO SISTEMA NERVOSO CENTRAL; USO DAS PROPRIEDADES DE INTERAÇÃO DE LIGANTES COM O CENTRO ATIVO DA EOPA ATUANDO QUER COMO INIBIDORES DA SUA AÇÃO ENZIMÁTICA E/OU ALTERANDO A SUA ASSOCIAÇÃO COM OUTRAS PROTEÍNAS INTRACELULARES, ÚTEIS NO TRATAMENTO DE PATOLOGIAS NEUROLÓGICAS, PSIQUIÁTRICAS E DEGENERATIVAS PI0305688-0 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Antonio Carlos Martins de Camargo; Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Juliano Rodrigo Guerreiro - December 2003, 05
PROCESSO DE ISOLAMENTO E PURIFICAÇÃO DE PEPTÍDEOS INIBIDORES DAS VASOPEPTIDASES, COM ESPECIFICIDADE PARA O SÍTIO CARBOXÍLICO DA ENZIMA CONVERSORA DA ANGIOTENSINA, SECRETADOS PELAS GLÂNDULAS DO VENENO DE SERPENTES (BPPS), PARTICULARMENTE BOTHROPS JARARACA, OU PRODUZIDOS ENDOGENAMENTE (EVASINS) POSSUINDO AÇÃO VASODILATADORA E ANTI-HIPERTENSIVA; PROCESSO DE DETERMINAÇÃO DA SEQUÊNCIA DE AMIDO-ÁCIDOS DOS PEPTÍDIOS INIBIDORES SECRETADOS PELA GLÂNDULA DE VENENO DE SERPENTES (BPPS) OU ENDÓGENOS (EVASINS); PROCESSO DE DETERMINAÇÃO DA SEQUÊNCIA DE AMINOÁCIDOS DOS BPPS POR DEDUÇÃO DO CDNA DOS PRECURSORES DESSAS MOLÉCULAS EXPRESSOS EM TECIDOS DE SERPENTES, ESPECIFICAMENTE BOTHROPS JARARACA. PROCESSO DE DETERMINAÇÃO DA SEQÜÊNCIA DE AMINOÁCIDOS DOS EVASINS POR DEDUÇÃO DO CDNA DOS PRECURSORES DESSAS MOLÉCULAS EXPRESSOS EM TECIDOS DE SERPENTES, ESPECIFICAMENTE BOTHROPS JARARACA, PROCESSO DE AMPLIFICAÇÃO DO CDNA A PARTIR DAS BIBLIOTECAS DE CDNA DE PÂNCREAS E/OU CÉREBRO DE SERPENTES, ESPECIFICAMENTE BOTHROPS JARARACA; PROCESSO DE SÍNTESE EM FASE SÓLIDA DE PEPTÍDEOS INIBIDORES DAS VASOPEPTIDASES COM AÇÃO VASODILATADORA E ANTI-HIPERTENSIVA, PEPTÍDEOS INIBIDORES DAS VASOPEPTIDASES COM AÇÃO ANTI-HIPERTENSIVA; UTILIZAÇÃO DOS PEPTÍDEOS INIBIDORES DAS VASO PEPTIDASES COM AÇÃO VASODILATADORA E ANTI-HIPERTENSIVA NA OBTENÇÃO DE COMPOSIÇÕES FARMACÊUTICAS; PROCESSO DE DETERMINAÇÃO DA ATIVIDADE INIBITÓRIA SOBRE AS VASOPEPTIDASES E DE ATIVIDADE BIOLÓGICA SOBRE MÚSCULO LISO, SISTEMA CARDIOVASCULAR E MICROCIRCULATÓRIO. PI0101088-3 - Antonio Carlos Martins de Camargo; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Antonio Carlos Martins de Camargo; Alessandra Ferragini Murbach; Danielle Alves Ianzer; Sandra Helena Poliselli Farsky; Mario Sergio Palma - March 2002, 18
PROCESSO PARA A DETERMINAÇÃO DA ESTRUTURA PRIMÁRIA DO RNA MENSAGEIRO CODIFICANTE PARA A ENDOOLIGOPEPTIDASE HUMANA RECOMBINANTE - A HEOPA E DA SUA SEQUÊNCIA PROTEICA, PARA A DETERMINAÇÃO DO GENE DA EOPA HUMANA E PARA A PRODUÇÃO DA EOPA HUMANA RECOMBINANTE; PROCESSO DE GERAÇÃO DE ANTICORPO ANTI-EOPA HUMANA POLICLONAIS E EM CAMUNDONGOS; PROCESSO DE CARACTERIZAÇÃO E SUBSTRATOS SINTÉTICOS DAS PROPRIEDADES BIOQUÍMICAS E PROTEOLÍTICAS DA EOPA E ANTICORPOS INIBIDORES DA ATIVIDADE CATALÍTICA E DE INTERAÇÃO COM OLIGOPEPTÍDEOS; COMPETIDORES E ANTAGONISTAS; MÉTODO DE IDENTIFICAÇÃO DE CONDIÇÕES DE PATOLOGIAS CONGÊNITAS, INFECCIOSAS E DEGENERATIVAS DO SISTEMA NERVOSO CENTRAL E DE DETERMINAÇÃO DO PAPEL DA EOPA EM PROCESSOS IMUNOLÓGICOS; MÉTODO DE DIAGNÓSTICO, PREVENÇÃO OU TRATAMENTO DE DOENÇAS CONGÊNITAS, INFECCIOSAS E DEGENERATIVAS DO SISTEMA NERVOSO CENTRAL; USO DE INIBIDORES E COMPETIDORES E SEUS DERIVADOS, PARA O TRATAMENTO DE PATOLOGIAS NEUROLÓGICAS E DEGENERAÇÕES TECIDUAIS PI0205000-5 - Antonio Carlos Martins de Camargo. Mirian Akemi Furuie Hayashi; Fernanda Calheta Vieira Portaro; Juliano Rodrigo Guerreiro; Antonio Carlos Martins de Camargo - December 2002, 09
USO DE CROTAMINA, KIT E COMPOSIÇÃO PI0501037-3 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Tetsuo Yamane; Irina Kerkis; Alexandre Kerkis; Gandhi Rádis Baptista; Mirian Akemi Furuie Hayashi; Katsuhiro Konno; Álvaro Rossan de Brandão Prieto da Silva; Lygia da Veiga Pereira; Eduardo Brandt de Oliveira - March 2005, 18
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