An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

Author(s)

Ali, Akbar ^[1] ; Correa, Arlene G. ^[1] ; Alves, Diego ^[2] ; Zukerman-Schpector, Julio ^[1] ; Westermann, Bernhard ^[3] ; Ferreira, Marco A. B. ^[1] ; Paixao, Marcio W. ^[1]

Affiliation

^[1] Univ Fed Sao Carlos UFSCar, Dept Chem, Sao Carlos, SP - Brazil

^[2] Univ Fed Pelotas UFPel, Dept Chem, Pelotas, RS - Brazil

^[3] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, Halle - Germany

• Document type: Journal article
• Source: CHEMICAL COMMUNICATIONS; v. 50, n. 80, p. 11926-11929, 2014.
• Web of Science Citations: 44

Abstract

A simple and efficient metal-free methodology for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles has been developed by applying a novel inverse electron-demand-1,3-dipolar cycloaddition approach. The practical one-pot metal-free strategy can be accomplished with various alkylidene malononitriles and aromatic azides in the presence of base. (AU)

• FAPESP's process: 13/02311-3 - New approaches in asymmetric synthesis of tetrahydrofuran and tetrahydropyran-derivatives with potential application in the preparation of bioactive molecules
• Grantee: Marco Antonio Barbosa Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/54040-8 - Acquisition of a high-resolution Orbitrap mass spectrometer for the discovery and structural analysis of biologically active compounds: applications in proteomics, biomarkers, synthesis, isolation, and characterization of natural products, studies of redox systems in food and enzymatic synthesis
• Grantee: Emanuel Carrilho
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
• Grantee: Márcio Weber Paixão
• Support Opportunities: Research Grants - Young Investigators Grants