| Full text | |
| Author(s): Show less - |
Faria, Karma Morais
[1, 2]
;
Brandao, Thais Bianca
[3]
;
Prado Ribeiro, Ana Carolina
[3]
;
Gouvea Vasconcellos, Adriele Ferreira
[3]
;
de Carvalho, Icaro Thiago
[4]
;
de Arruda, Fernando Freire
[4]
;
Castro Junior, Gilberto
[5]
;
Gross, Vanessa Cristina
[1, 2]
;
Almeida, Oslei Paes
[1, 2]
;
Lopes, Marcio Ajudarte
[1, 2]
;
Santos-Silva, Alan Roger
[1, 2]
Total Authors: 11
|
| Affiliation: | [1] Univ Estadual Campinas, UNICAMP, Dept Oral Diag, Semiol Area, Piracicaba Dent Sch, BR-13414903 Sao Paulo - Brazil
[2] Univ Estadual Campinas, UNICAMP, Dept Oral Diag, Pathol Area, Piracicaba Dent Sch, BR-13414903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Dental Oncol Serv, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Radiotherapy Serv, Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Clin Oncol Serv, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | JOURNAL OF ENDODONTICS; v. 40, n. 10, p. 1553-1559, OCT 2014. |
| Web of Science Citations: | 11 |
| Abstract | |
Introduction: Teeth are often included in the radiation field during head and neck radiotherapy, and recent clinical evidence suggests that dental pulp is negatively affected by the direct effects of radiation, leading to impaired sensitivity of the dental pulp: Therefore, this study aimed to investigate the direct effects of radiation on the microvasculature, innervation, and extracellular matrix of the dental pulp of patients who have undergone head and neck radiotherapy. Methods: Twenty-three samples of dental pulp from patients who finished head and neck radiotherapy were analyzed. Samples were histologically processed and stained with hematoxylin-eosin for morphologic evaluation of the microvasculature, innervation, and extracellular matrix. Subsequently, immunohistochemical analysis of proteins related to vascularization (CD34 and smooth muscle actin), innervation (S-100, NCAM/CD56, and neurofilament), and extracellular matrix (vimentin) of the dental pulp was performed. Results: The morphologic study identified preservation of the microvasculature, nerve bundles, and components of the extracellular matrix in all studied samples. The immunohistochemical analysis confirmed the morphologic findings and showed a normal pattern of expression for the studied proteins in all samples. Conclusions: Direct effects of radiotherapy are not able to generate morphologic changes in the microvasculature, innervation, and extracellular matrix components of the dental pulp in head and neck cancer patients. (AU) | |
| FAPESP's process: | 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma |
| Grantee: | Ana Carolina Prado Ribeiro e Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients |
| Grantee: | Alan Roger dos Santos Silva |
| Support Opportunities: | Regular Research Grants |