Silver complexes with sulfathiazole and sulfamethoxazole: Synthesis, spectroscopic characterization, crystal structure and antibacterial assays

Author(s)

Bormio Nunes, Julia Helena ^[1] ; Ferraz de Paiva, Raphael Enoque ^[1] ; Cuin, Alexandre ^[2] ; Lustri, Wilton Rogerio ^[3] ; Corbi, Pedro Paulo ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Bioinorgan & Med Chem Res Lab, BR-13083970 Campinas, SP - Brazil

^[2] Univ Fed Juiz de Fora, Bioinorgan Chem Res Lab, BR-36036330 Juiz De Fora, MG - Brazil

^[3] Centro Univ Araraquara, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Polyhedron; v. 85, p. 437-444, JAN 8 2015.
• Web of Science Citations: 22

Abstract

The present work describes the synthesis and spectroscopic characterization of two silver(I) complexes with the sulfonamides sulfathiazole (AgC9H8N3O2S2, Ag-SFF) and sulfamethoxazole (AgC10H10N3O3S, Ag-SFM). Elemental analyses indicate a 1:1 metal/ligand composition for both complexes. Spectroscopic techniques such as H-1, N-15 NMR and IR evidence the coordination of both ligands to silver through the nitrogen atom of the sulfonamide group, and also indicate the participation of the 5-membered N-heterocyclic ring in the coordination. The Ag-SFT crystal structure was solved by X-ray powder diffraction and indicates the formation of a dimeric structure with silver bridging between two ligand molecules. Biological studies showed the antibacterial activity of Ag-SFT and Ag-SFM complexes against Gram-positive and Gram-negative bacterial strains, with MIC values ranging from 3.45 to 6.90 mmol L-1 for the sulfathiazole complex and 1.74 to 13.9 mmol L-1 for the sulfamethoxazole complex. The complexes have shown to be more active against Gram-negative bacterial strains. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/08230-2 - Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants