HDL Size is More Accurate than HDL Cholesterol to Predict Carotid Subclinical Atherosclerosis in Individuals Classified as Low Cardiovascular Risk

Author(s):Show less -

Parra, Eliane Soler ^{[1, 2, 3]} ; Panzoldo, Natalia Baratella ^{[1, 2, 3]} ; de Souza Zago, Vanessa Helena ^{[1, 2]} ; Scherrer, Daniel Zanetti ^{[1, 2]} ; Alexandre, Fernanda ^{[1, 2]} ; Bakkarat, Jamal ^{[1, 2]} ; Nunes, Valeria Sutti ^[4] ; Nakandakare, Edna Regina ^[4] ; Rocha Quintao, Eder Carlos ^[4] ; Nadruz-, Jr., Wilson ^[3] ; de Faria, Eliana Cotta ^{[1, 2]} ; Sposito, Andrei C. ^[3]

Affiliation

^[1] Univ Estadual Campinas, Dept Clin Pathol, Fac Med Sci, Lipid Lab, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Ctr Med & Expt Surg, Fac Med Sci, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Med Sci, Dept Cardiol, Campinas, SP - Brazil

^[4] Univ Sao Paulo, Lipid Lab, Fac Med Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS One; v. 9, n. 12 DEC 3 2014.
• Web of Science Citations: 3

Abstract

Background: Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR. Methods and Findings: 284 individuals (40-75 years) classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS) technique. Participants were classified in tertiles of HDL size (<7.57; 7.57-8.22; >8.22 nm). Carotid intima-media thickness (cIMT) <0.90 mm (80th percentile) was determined by high resolution ultrasonography and multivariate ordinal regression models were used to assess the association between cIMT across HDL size and levels of lipid parameters. HDLcholesterol was not associated with cIMT. In contrast, HDL size >8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p=0.013). Conclusion: The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR. (AU)

• FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
• Grantee: Eder Carlos Rocha Quintão
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 11/16476-9 - Physico-chemical and biochemical studies of high density lipoprotein in states of hypo and hyperalphalipoproteinemia: association with carotid artery intima-media thickness
• Grantee: Fernanda Alexandre
• Support Opportunities: Scholarships in Brazil - Master