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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Alveolar bone dynamics in osteoporotic rats treated with raloxifene or alendronate: confocal microscopy analysis

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Author(s):
Ramalho-Ferreira, Gabriel [1, 2] ; Faverani, Leonardo Perez [1, 2] ; Grossi-Oliveira, Gustavo Augusto [1, 2] ; Okamoto, Tetuo [1, 2] ; Okamoto, Roberta [3]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Surg, BR-16015050 Sao Paulo - Brazil
[2] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Integrated Clin, BR-16015050 Sao Paulo - Brazil
[3] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, BR-16015050 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Biomedical Optics; v. 20, n. 3 MAR 2015.
Web of Science Citations: 5
Abstract

In this study, the characteristics of the alveolar bone of rats with induced osteoporosis were examined. Thirty-two rats were divided into four groups according to the induction of osteoporosis and drugs administered: OG, osteoporotic rats without treatment (negative control); SG, rats which underwent sham surgery ovariectomy (SHAM); alendronate (AG), osteoporotic rats treated with alendronate; and RG, osteoporotic rats treated with raloxifene (RG). On the 8th day after ovariectomy and SHAM surgeries, drug therapy was started with AG or RG. On the 52nd day, 20 mg/kg calcein was administered to all of the rats, and on the 80th day, 20 mg/kg alizarin red was administered. Euthanasia was performed on the 98th day. The bone area marked by fluorochromes was calculated and data were subjected to two-way ANOVA test and Tukey's post-hoc test (p < 0.05). The comparison of the induced osteoporosis groups showed no statistically significant differences in bone turnover only between RG and SG (p = 0.074) and AG and OG (p = 0.138). All other comparisons showed significant differences (p < 0.001). The largest bone turnover was observed in RG and SG groups. RG was the medication that improved the dynamics of the alveolar bone of rats with induced osteoporosis, resembling that of healthy rats. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

FAPESP's process: 10/13971-6 - In vitro study of changes in the surface of commercially pure titanium and titanium alloy Ti-6Al-4V subjected to different treatments
Grantee:Leonardo Perez Faverani
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/15912-2 - Evaluation of bone repair in the bone / implant interface in osteoporotic rats treated with raloxifene or alendronate: a histometrical, immunohistochemical, epifluorescence and biomecanical analysis
Grantee:Roberta Okamoto
Support Opportunities: Regular Research Grants