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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents

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Author(s):
Landi Masquio, Deborah Cristina [1] ; Ganen, Aline de Piano [1] ; da Silveira Campos, Raquel Munhoz [1] ; Sanches, Priscila de Lima [1] ; Corgosinho, Flavia Campos [1] ; Caranti, Danielle [2] ; Tock, Lian [3] ; de Mello, Marco Tulio [1] ; Tufik, Sergio [4] ; Damaso, Ana R. [1, 2]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Postgrad Program Nutr, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos, SP - Brazil
[3] Weight Sci, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NUTRICION HOSPITALARIA; v. 31, n. 4, p. 1540-1550, APR 2015.
Web of Science Citations: 9
Abstract

Introduction: Metabolic syndrome (MetS) is a constellation of metabolic alterations related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. The aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS. Methods: 195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICK' and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system. Results: We observed a prevalence of 25% of MetS (n=50). The MetS group presented significantly higher body mass, BlVH, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, blood pressure and non-alcoholic fatty liver disease (NAFLD). Significant lower QUICKI and adiponectin were noted in MetS group. MetS girls presented significantly higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positively correlated with visceral fat and the number of metabolic syndrome parameters. Conclusion: MetS group presented significantly higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants