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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study

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Author(s):
Zambom de Souza, Alessandra Zanin [1] ; Zambom, Adriano Zanin [2] ; Abboud, Kahlile Youssef [1] ; Reis, Sabrina Karen [1] ; Tannihao, Fabiana [1] ; Guadagnini, Dioze [3] ; Saad, Mario J. A. [3] ; Prada, Patricia Oliveira [1, 3]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Sch Appl Sci, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Stat, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Internal Med, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NUTRITION; v. 31, n. 6, p. 884-889, JUN 2015.
Web of Science Citations: 18
Abstract

Objective: The aim of this study was to determine whether oral supplementation with L-glutamine (GLN) modifies the gut microbiota composition in overweight and obese adults. Methods: Thirty-three overweight and obese adults, ages between 23 and 59 y and body mass index between 25.03 and 47.12 kg/m(2), were randomly assigned to receive either oral supplementation with 30 g of L-alanine (ALA group control) or 30 g of GLN (GLN group) daily for 14 d. We analyzed the gut microbiota composition with new-generation sequencing techniques and bioinformatics analysis. Results: After 14 d of supplementation, adults in the GLN group exhibited statistically significant differences in the Firmicutes and Actinobacteria phyla compared with those in the ALA group. The ratio of Firmicutes to Bacteroidetes, a good biomarker for obesity, decreased in the GLN group from 0.85 to 0.57, whereas it increased from 0.91 to 1.12 in the ALA group. At the genus level, Dialister, Dorea, Pseudobutyrivibrio, and Veillonella, belonging to the Firmicutes phylum, had statistically significant reduction. Conclusion: Oral supplementation with GLN, for a short time, altered the composition of the gut microbiota in overweight and obese humans reducing the Firmicutes to Bacteroidetes ratio, which resembled weight loss programs already seen in the literature. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/10338-6 - The regulation of Clk2 and IKK epsilon in the hypothalamus of obese mice
Grantee:Patrícia de Oliveira Prada
Support Opportunities: Regular Research Grants