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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

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Author(s):
Luvizotto, R. A. M. [1, 2] ; Nascimento, A. F. [2] ; Miranda, N. C. M. [1] ; Wang, X-D [3] ; Ferreira, A. L. A. [1]
Total Authors: 5
Affiliation:
[1] Botucatu Med Sch UNESP, Dept Internal Med, Sao Paulo - Brazil
[2] Fed Univ Mato Grosso UFMT, Inst Hlth Sci, BR-78557267 Sinop, MG - Brazil
[3] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 - USA
Total Affiliations: 3
Document type: Journal article
Source: HUMAN & EXPERIMENTAL TOXICOLOGY; v. 34, n. 6, p. 612-619, JUN 2015.
Web of Science Citations: 14
Abstract

Aim: To investigate whether lycopene can modulate adiponectin levels and SIRT1 and FoxO1 gene expression in the adipose tissue of diet-induced obese rats. Methods: Male Wistar rats were first fed with hypercaloric diet (HD, n = 12) for 6 weeks, and afterward, these rats were randomly assigned to receive HD (n = 6) or HD with lycopene-rich tomato oleoresin (equivalent to lycopene 10 mg/kg body weight (BW)/day, HD + L, n = 6) by gavage for additional 6 weeks. Plasma lycopene and adiponectin levels were analyzed by high-performance liquid chromatography and immunoassay, respectively. The messenger RNA (mRNA) expressions of adiponectin, Sirtuin 1 (SIRT1), Forkhead box O 1 (FoxO1), fatty acid translocase/cluster of differentiation 36 (FAT/CD36), and PPAR in adipose tissues were determined by quantitative polymerase chain reaction. Results: Lycopene was detected in the plasma of rats in HD + L group but not in the HD group. Although both BW and adiposity were not different between the two groups, there was a significant increase in both plasma concentration and mRNA expression of adiponectin in the adipose tissue of the HD + L group. In addition, the lycopene supplementation upregulated mRNA expressions of SIRT1, FoxO1, and FAT/CD36 but downregulated PPAR in adipose tissue of obese rats. Conclusion: These data suggest that lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications. (AU)

FAPESP's process: 11/22786-0 - Influence of lycopene on oxidative stress markers in adipose tissue of obese rats
Grantee:Renata de Azevedo Melo Luvizotto Nascimento
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 11/19934-8 - Influence of lycopene on adiponectin levels in adipose tissue of animals subject to hyper caloric diet
Grantee:Natália Carla Martins Miranda
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/19746-4 - Effect of lycopene supplementation in experimental model of diet-induced obesity
Grantee:Renata de Azevedo Melo Luvizotto Nascimento
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 10/06100-9 - Effect of lycopene supplementation on obesity in experimental model Zucker rats
Grantee:Ana Lucia do Anjos Ferreira
Support Opportunities: Regular Research Grants