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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Resting Heart Rate Is Not a Good Predictor of a Clustered Cardiovascular Risk Score in Adolescents: The HELENA Study

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Author(s):
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Ferreira de Moraes, Augusto Cesar [1, 2, 3] ; Cassenote, Alex Jones Flores [4] ; Leclercq, Catherine [5] ; Dallongeville, Jean [6] ; Androutsos, Odysseas [7] ; Toeroek, Katalin [8] ; Gonzalez-Gross, Marcela [9, 10] ; Widhalm, Kurt [11] ; Kafatos, Anthony [12] ; Carvalho, Heraclito Barbosa [1, 3] ; Alberto Moreno, Luis [2, 1]
Total Authors: 11
Affiliation:
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[1] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil
[2] Univ Zaragoza, Fac Ciencias Salud, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza - Spain
[3] Univ Sao Paulo, Sch Med, YCARE Youth Child & cARdiovasc Risk & Environm Re, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, Sao Paulo - Brazil
[5] Natl Inst Food & Nutr Res, Rome - Italy
[6] Inst Pasteur, F-59019 Lille - France
[7] Harokopio Univ, Dept Nutr & Dietet, Athens - Greece
[8] Univ Pecs, Fac Med, Dept Paediat, Pecs - Hungary
[9] Tech Univ Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, Madrid - Spain
[10] Univ Bonn, Rhein Friedrich Wilhelms, Inst Ernahrungs & Lebensmittelwissensch Humanemah, Dortmund - Germany
[11] Private Med Univ Salzburg, Dept Paediat, Salzburg - Austria
[12] Univ Crete Herakl, Sch Med, Prevent Med & Nutr Unit, Iraklion, NE - Greece
Total Affiliations: 12
Document type: Journal article
Source: PLoS One; v. 10, n. 5 MAY 26 2015.
Web of Science Citations: 1
Abstract

Background Resting heart rate (RHR) reflects sympathetic nerve activity a significant association between RHR and all-cause and cardiovascular mortality has been reported in some epidemiologic studies. Methods To analyze the predictive power and accuracy of RHR as a screening measure for individual and clustered cardiovascular risk in adolescents. The study comprised 769 European adolescents (376 boys) participating in the HELENA cross-sectional study (2006-2008) were included in this study. Measurements on systolic blood pressure, HOMA index, triglycerides, TC/HDL-c, VO(2)max and the sum of four skinfolds were obtained, and a clustered cardiovascular disease (CVD) risk index was computed. The receiver operating characteristics curve was applied to calculate the power and accuracy of RHR to predict individual and clustered CVD risk factors. Results RHR showed low accuracy for screening CVD risk factors in both sexes (range 38.5%-54.4% in boys and 45.5%-54.3% in girls). Low specificity's (15.6%-19.7% in boys; 18.1%-20.0% in girls) were also found. Nevertheless, the sensitivities were moderate-to-high (61.4%-89.1% in boys; 72.9%-90.3% in girls). Conclusion RHR is a poor predictor of individual CVD risk factors and of clustered CVD and the estimates based on RHR are not accurate. The use of RHR as an indicator of CVD risk in adolescents may produce a biased screening of cardiovascular health in both sexes. (AU)

FAPESP's process: 11/20662-2 - High blood pressure and aggregation of risk factors in adolescents: a multicenter study
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/13367-2 - Design and implementation of methods to assess behaviors related to energy balance in children/adolescents in a multicenter study: SAYCARE study
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/11137-1 - High blood pressure and aggregation of risk factors in adolescents: a multicenter study
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships in Brazil - Doctorate