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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor

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Author(s):
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Gleber-Netto, Frederico O. [1] ; Braakhuis, Boudewijn J. M. [2] ; Triantafyllou, Asterios [3, 4] ; Takes, Robert P. [5] ; Kelner, Natalie [6] ; Rodrigo, Juan P. [7, 8] ; Strojan, Primoz [9] ; Vander Poorten, Vincent [10] ; Rapidis, Alexander D. [11] ; Rinaldo, Alessandra [12] ; Brakenhoff, Ruud H. [2] ; Ferlito, Alfio [13] ; Kowalski, Luiz P. [14, 6]
Total Authors: 13
Affiliation:
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[1] AC Camargo Canc Ctr, Int Res Ctr, Lab Med Genom, Sao Paulo - Brazil
[2] Vrije Univ Amsterdam Med Ctr, Dept Otolaryngol Head & Neck Surg, Amsterdam - Netherlands
[3] Univ Liverpool, Sch Dent, Oral & Maxillofacial Pathol, Liverpool L69 3BX, Merseyside - England
[4] Aintree Univ Hosp NHS Fdn Trust, Cellular Pathol, Liverpool L9 7AL, Merseyside - England
[5] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-6525 ED Nijmegen - Netherlands
[6] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
[7] Univ Oviedo, Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo - Spain
[8] Inst Univ Oncol Principado Asturias, Oviedo - Spain
[9] Inst Oncol, Dept Radiat Oncol, Ljubljana - Slovenia
[10] Univ Hosp KU Leuven, Dept Oncol Sect Head & Neck Oncol, Otorhinolaryngol Head & Neck Surg, Leuven - Belgium
[11] St Savvas Hosp, Greek Anticanc Inst, Dept Head & Neck Surg, Athens - Greece
[12] Univ Udine, Sch Med, I-33100 Udine - Italy
[13] AC Camargo Canc Ctr, Int Head & Neck Sci Grp, Sao Paulo - Brazil
[14] Natl Inst Sci & Technol Oncogen INCITO, Sao Paulo - Brazil
Total Affiliations: 14
Document type: Review article
Source: Oral Oncology; v. 51, n. 8, p. 738-744, AUG 2015.
Web of Science Citations: 14
Abstract

Relapses have a great impact on both the morbidity and mortality rates of oral squamous cell carcinoma (OSCC) patients. Current classification criteria are imprecise and need improvements. Recent advances in understanding of OSCC relapses on a molecular level provide new possibilities to better classify true recurrences and second primary tumors. This review discusses the limitations of the current OSCC relapse classification method and presents possible alternatives to improve this classification based on molecular techniques. Moreover, these molecular techniques add to the further understanding of these lesions and may provide tools for clinical management. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/13315-4 - Large-scale study of transcriptional alterations associated with the development of metastasis in oral cancer.
Grantee:Frederico Omar Gleber Netto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/09142-2 - Study of salivary markers of nodal metastasis in oral squamous cell carcinoma
Grantee:Frederico Omar Gleber Netto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate