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Study of salivary markers of nodal metastasis in oral squamous cell carcinoma

Grant number: 13/09142-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): January 02, 2014
Effective date (End): January 01, 2015
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Emmanuel Dias-Neto
Grantee:Frederico Omar Gleber Netto
Supervisor abroad: David T. W. Wong
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Research place: University of California, Los Angeles (UCLA), United States  
Associated to the scholarship:11/13315-4 - Large-scale study of transcriptional alterations associated with the development of metastasis in oral cancer., BP.DR


Nodal metastasis is the main prognostic factor for oral cancer patients. However, current technologies do not allow a reliable diagnosis of the metastatic dissemination to lymph nodes. In this way, the discovery of molecular markers of nodal metastasis will be of great value to prognosis and treatment of oral cancer patients. Salivary analysis has been described as a good diagnostic tool for diverse pathological conditions, including cancer. Due to its non-invasive collection procedure and simple manipulation, saliva can be an important source of information regarding oncologic patients. Moreover, the complementarity between the molecular expression pattern found in cancer tissue and plasma with saliva has been demonstrated. Considering this, the aim of this work is to search for molecular markers of nodal metastasis in saliva of oral cancer patients through salivary RNA-Seq, real-time PCR and salivary exosome analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GLEBER-NETTO, FREDERICO O.; NESKEY, DAVID; DE MATTOS COSTA, ANA FLAVIA; KATARIA, PRANAV; RAO, XIAYU; WANG, JING; KOWALSKI, LUIZ PAULO; PICKERING, CURTIS R.; DIAS-NETO, EMMANUEL; MYERS, JEFFREY N. Functionally impactfulTP53mutations are associated with increased risk of extranodal extension in clinically advanced oral squamous cell carcinoma. Cancer, AUG 2020. Web of Science Citations: 0.
GLEBER-NETTO, FREDERICO OMAR; YAKOB, MAHA; LI, FENG; FENG, ZIDING; DAI, JIANLIANG; KAO, HUANG-KAI; CHANG, YU-LIANG; CHANG, KAI-PING; WONG, DAVID T. W. Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population. Clinical Cancer Research, v. 22, n. 13, p. 3340-3347, JUL 1 2016. Web of Science Citations: 12.
GLEBER-NETTO, FREDERICO O.; BRAAKHUIS, BOUDEWIJN J. M.; TRIANTAFYLLOU, ASTERIOS; TAKES, ROBERT P.; KELNER, NATALIE; RODRIGO, JUAN P.; STROJAN, PRIMOZ; VANDER POORTEN, VINCENT; RAPIDIS, ALEXANDER D.; RINALDO, ALESSANDRA; BRAKENHOFF, RUUD H.; FERLITO, ALFIO; KOWALSKI, LUIZ P. Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor. Oral Oncology, v. 51, n. 8, p. 738-744, AUG 2015. Web of Science Citations: 14.

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