Functional photostability and cutaneous compatibility of bioactive UVA sun care products

Author(s):Show less -

de Oliveira, Camila Areias ^[1] ; Peres, Daniela DAlmeida ^[1] ; Rugno, Caynan Mendes ^[1] ; Kojima, Mayara ^[1] ; Sales de Oliveira Pinto, Claudineia Aparecida ^[1] ; Consiglieri, Vladi Olga ^[1] ; Kaneko, Telma Mary ^[1] ; Rosado, Catarina ^[2] ; Mota, Joana ^[2] ; Robles Velasco, Maria Valeria ^[1] ; Baby, Andre Rolim ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Pharm, BR-05508900 Sao Paulo, SP - Brazil

^[2] Lusofona Univ, CBIOS Res Ctr Biosci & Hlth Technol, P-1749024 Lisbon - Portugal

• Document type: Journal article
• Source: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; v. 148, p. 154-159, JUL 2015.
• Web of Science Citations: 19

Abstract

Sunscreens are the most-established approach for photoprotection. The strategy of providing antioxidant properties to sun care products by addition of natural and potent anti-free radical compounds has led to the development of bioactive sunscreens, able to neutralize the harmful effects of ultraviolet (UV) radiation. UVA filters, such as benzophenone-3 (BP) and butyl methoxydibenzoylmethane (BMDBM), can exhibit photodegradation which limits the development of broad spectrum sunscreens. Previous research verified that rutin interacts with filters incorporated in sunscreens. In this work, we focused on the development and evaluation of the efficacy of the sunscreens containing either BP or BMDBM with and without rutin. The addition of rutin to the UVA filters afforded antioxidant properties to the formulations and they were considered safe for human use. Additionally, rutin in combination with either BP or BMDBM increased the antioxidant activity about 40 times when compared with the UVA filters alone. Remarkably, the addition of rutin 0.1% (w/w) to BP 6.0% (w/w) raised the SPF from 24.3 +/- 1.53 to 33.3 +/- 2.89. In conclusion, these findings demonstrated that the addition of rutin into sunscreens can markedly improve the antioxidant properties of the formulation as well as photostabilize some of the UVA filters. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 10/05880-0 - Anti-UVA bioactive sunscreens: development and "in vitro" efficacy evaluation by reflectance spectrophotometry with integrated sphere
• Grantee: Caynan Mendes Rugno
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 08/57800-0 - Broad-spectrum sunscreens: conceptual and practical development of bioactive sunscreens
• Grantee: André Rolim Baby
• Support Opportunities: Regular Research Grants