| Full text | |
| Author(s): Show less - |
Maki-Nunes, Cristiane
[1]
;
Toschi-Dias, Edgar
[1]
;
Cepeda, Felipe X.
[1]
;
Rondon, Maria Urbana P. B.
[1, 2]
;
Alves, Maria-Janieire N. N.
[1]
;
Fraga, Raffael F.
[1]
;
Braga, Ana Maria F. W.
[1]
;
Aguilar, Adriana M.
[1]
;
Amaro, Aline C.
[3]
;
Drager, Luciano F.
[4]
;
Lorenzi-Filho, Geraldo
[3]
;
Negrao, Carlos E.
[1, 2]
;
Trombetta, Ivani C.
[1, 5]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Cardiovasc Rehabil & Exercise Physiol Unit, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, Biodinam, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sleep Lab, Pulm Div, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, Sao Paulo - Brazil
[5] Univ Nove De Julho UNINOVE, Programa Posgrad Med, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | OBESITY; v. 23, n. 8, p. 1582-1590, AUG 2015. |
| Web of Science Citations: | 11 |
| Abstract | |
ObjectiveChemoreflex hypersensitity was caused by obstructive sleep apnea (OSA) in patients with metabolic syndrome (MetS). This study tested the hypothesis that hypocaloric diet and exercise training (D+ET) would improve peripheral and central chemoreflex sensitivity in patients with MetS and OSA. MethodsPatients were assigned to: (1) D+ET (n=16) and (2) no intervention control (C, n=8). Minute ventilation (VE, pre-calibrated pneumotachograph) and muscle sympathetic nerve activity (MSNA, microneurography) were evaluated during peripheral chemoreflex sensitivity by inhalation of 10% O-2 and 90% N-2 with CO2 titrated and central chemoreflex by 7% CO2 and 93% O-2 for 3 min at study entry and after 4 months. ResultsPeak VO2 was increased by D+ET; body weight, waist circumference, glucose levels, systolic/diastolic blood pressure, and apnea-hypopnea index (AHI) (345.1 vs. 18 +/- 3.2 events/h, P=0.04) were reduced by D+ET. MSNA was reduced by D+ET at rest and in response to hypoxia (8.6 +/- 1.2 vs. 5.4 +/- 0.6 bursts/min, P=0.02), and VE in response to hypercapnia (14.8 +/- 3.9 vs. 9.1 +/- 1.2 l/min, P=0.02). No changes were found in the C group. A positive correlation was found between AHI and MSNA absolute changes (R=0.51, P=0.01) and body weight and AHI absolute changes (R=0.69, P<0.001). ConclusionsSympathetic peripheral and ventilatory central chemoreflex sensitivity was improved by D+ET in MetS+OSA patients, which may be associated with improvement in sleep pattern. (AU) | |
| FAPESP's process: | 08/03714-6 - Scan corporal sd para diagnostico de obesidade e avaliacao do risco cardiovascular. |
| Grantee: | Ivani Credidio Trombetta |
| Support Opportunities: | Scholarships abroad - New Frontiers |
| FAPESP's process: | 11/17533-6 - Autonomic, Metabolic and Inflammatory Aspects of Metabolic Syndrome Associated with Obstructive Sleep Apnea: Effect of Hypocaloric Diet and Physical Training |
| Grantee: | Ivani Credidio Trombetta |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/02953-2 - Impact of Obstructive Sleep Apnea and Sleep Duration on the Progression of Cardiovascular Diseases |
| Grantee: | Luciano Ferreira Drager |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 13/07651-7 - Prognostic value of the oscillatory pattern of muscle sympathetic nerve activity in patients with heart failure |
| Grantee: | Edgar Toschi Dias |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |