High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from Sao Paulo city, Brazil

Author(s)

Sales, Stephanie Hael ^[1] ; da Matta, Sandra ^[1] ; da Silva, Daniela Cardeal ^[2] ; Assone, Tatiane ^[2] ; Fonseca, Luiz Augusto M. ^[3] ; Duarte, Alberto J. S. ^[1] ; Casseb, Jorge ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunedeficiencies, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Trop Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 5, AUG 10 2015.
• Web of Science Citations: 4

Abstract

Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make their nutritional diagnoses, including their vitamin D blood levels, and to estimate their consumption of vitamin D. The study included 98 HIV-1-infected subjects, followed at University of Sao Paulo Medical School -HC-FMUSP. We performed a nutritional evaluation, along with the determination of patients' serum 25-hydroxyvitamin D and calcium concentration, biochemical analyses, and an anthropometric assessment. In the medical interview a 24-hour food recall was used (R24) to estimate daily calorie intake, macronutrients, calcium, and vitamin D. A high level of vitamin D deficiency was observed in our patients: 83.4% of them had levels below 30 ng/ml; they also presented an increased risk of cardiovascular disease, along with a high consumption of dietary fat. Factors related to the virus itself and to the use of antiretroviral drugs may have contributed for the low vitamin D levels seen in our HIV-1-infected patients. (AU)

• FAPESP's process: 11/04868-0 - PREVALENCE OF ABSORPTION AND DEFICIENCY OF VITAMIN D AND CALCIUM IN PATIENTS LIVING WITH HIV / AIDS
• Grantee: Stephanie Bianca Haél Sales
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/12311-6 - High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
• Grantee: Jorge Simao do Rosario Casseb
• Support Opportunities: Regular Research Grants - Publications - Scientific article