Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 - USA
Total Affiliations: 3
Bioorganic & Medicinal Chemistry Letters;
DEC 1 2015.
Web of Science Citations:
Polyalthic acid is a naturally occurring diterpene found in copaiba oil, one of the most popular natural medicines in the Amazon. Based on the reported antileishmanial activity of copaiba oil, a series of amides and diols derivatives of polyalthic acid were synthesized and tested against Leishmania donovani and Trypanosoma brucei. Polyalthic acid was active in both assays with IC50 ranging from 3.87 to 8.68 mu g/mL. The compound with best antileishmanial activity was 2h (IC50 = 3.84 mu g/mL) and compound 2c showed the best antitrypanosomal activity with an IC50 of 2.54 mu g/mL. (C) 2015 Elsevier Ltd. All rights reserved. (AU)