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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute Mucociliary Clearance Response to Aerobic Exercise in Smokers

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Author(s):
Ramos, Ercy M. C. [1] ; Vanderlei, Luiz Carlos M. [1] ; Ito, Juliana T. [1] ; Lima, Fabiano F. [1] ; Rodrigues, Fernanda M. M. [1] ; Manzano, Beatriz M. [2] ; Fernandes, Romulo A. [3] ; Cecilio, Michel J. [4] ; Toledo-Arruda, Alessandra C. [5] ; Ramos, Dionei [1]
Total Authors: 10
Affiliation:
[1] Univ Estadual Paulista UNESP, Dept Physiotherapy, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, EPM, Dept Pulmonol, Sao Paulo - Brazil
[3] Univ Estadual Paulista UNESP, Dept Phys Educ, Sao Paulo - Brazil
[4] Univ Oeste Paulista UNOESTE, Dept Med, Sao Paulo - Brazil
[5] Univ Sao Paulo FMUSP, Fac Med, Dept Clin Med, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Respiratory Care; v. 60, n. 11, p. 1575-1584, NOV 2015.
Web of Science Citations: 2
Abstract

BACKGROUND: Mucociliary clearance is the main defense mechanism of the respiratory system, and it is influenced by several stimuli, including aerobic exercise and cigarette smoking. We evaluated the acute response of mucociliary clearance to aerobic exercise in smokers and nonsmokers compared with that found after acute smoking and smoking combined with exercise. Also, we investigated whether there was a correlation between mucociliary clearance and the autonomic nervous system under these conditions. METHODS: Twenty-one smokers were evaluated for mucociliary clearance by saccharin transit time (STT), and the response of the autonomic nervous system was evaluated by heart rate variability after aerobic exercise, after exercise followed by smoking, after acute smoking, and after rest. For comparison, 17 nonsmokers were also assessed during exercise. Repeated-measures analysis of variance with the Tukey test or the Friedman test followed by the Dunn test was used to evaluate the STT, autonomic response, and other variables to exercise and/or smoking in smokers. A paired t test or Wilcoxon test was used to analyze responses to exercise in nonsmokers. Correlations were evaluated using Pearson or Spearman coefficients. RESULTS: The STT was reduced after exercise in both groups, with similar responses between them. Other stimuli also reduced the STT. The STT showed a negative correlation with sympathetic activity in smokers and a positive correlation with the parasympathetic system in nonsmokers. CONCLUSIONS: Although impaired in smokers, mucociliary clearance responded to the stimulus of exercise, as demonstrated by similar STTs compared with nonsmokers. This response was correlated with the autonomic nervous system in both groups. In smokers, mucociliary clearance also responded to the stimuli of smoking and exercise followed by smoking. (AU)

FAPESP's process: 12/04699-6 - Acute effect of moderate aerobic exercise in smokers' mucociliary clearance
Grantee:Juliana Tiyaki Ito
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/09932-0 - Effects of regular aerobic exercise in mice exposed to cigarette smoke: temporal profile of the inflammatory response and oxidative stress
Grantee:Alessandra Choqueta de Toledo
Support type: Scholarships in Brazil - Post-Doctorate