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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Flow injection simultaneous determination of acetaminophen and tramadol in pharmaceutical and biological samples using multiple pulse amperometric detection with a boron-doped diamond electrode

Full text
Author(s):
Santos, Anderson M. [1] ; Vicentini, Fernando C. [1] ; Figueiredo-Filho, Luiz C. S. [1, 2] ; Deroco, Patricia B. [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Parana, BR-87703536 Paranavai, PR - Brazil
Total Affiliations: 2
Document type: Journal article
Source: DIAMOND AND RELATED MATERIALS; v. 60, p. 1-8, NOV 2015.
Web of Science Citations: 18
Abstract

An analytical procedure was developed for the simultaneous determination of acetaminophen (ACP) and tramadol (TRA) by flow injection analysis with multiple pulse amperometric detection (FIA-MPA) using a cathodically pretreated boron-doped diamond electrode (BDDE). The proposed method was applied to the simultaneous determination of ACP and TRA in pharmaceutical samples and synthetic biological fluids. The obtained results are in acceptable levels, the proposed method presents low RSD values (<2.70 and 4.70% for intra- and inter-day, respectively), linear ranges from 1.0 to 100 mu mol L-1 for ACP and from 0.08 to 10 mu mol L-1 for TRA, limits of detection of 0.03 and 0.04 mu mol L-1 for ACP and TRA, respectively, elevated analytical frequency (approximately 85 injections h(-1)) and adequate accuracy (confirmed by comparison with HPLC results). (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/16770-0 - SENSORS DEVELOPMENT BASED ON POLYMERIC FILMS AND NANOMATERIALS FOR SEVERAL ANALYTICAL APPLICATIONS
Grantee:Fernando Campanhã Vicentini
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/07919-2 - Preparation of electrodes with new carbon-based materials for applications in electroanalytical
Grantee:Patrícia Batista Deroco
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/04284-6 - Electrochemical studies and application of sensors based on graphene or 3-D reticuled glassy carbon modified with metal nanoparticles for determination of pharmaceuticals and environmental analytes.
Grantee:Luiz Carlos Soares de Figueiredo Filho
Support type: Scholarships in Brazil - Post-Doctorate