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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Macrophage Switch in Obesity Development

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Author(s):
Castoldi, Angela [1] ; de Souza, Cristiane Naffah [1] ; Saraiva Camara, Niels Olsen [1, 2, 3] ; Moraes-Vieira, Pedro M. [4]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Med, Lab Renal Physiol LIM 16, Sao Paulo - Brazil
[4] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02115 - USA
Total Affiliations: 4
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 6, JAN 5 2016.
Web of Science Citations: 118
Abstract

Immune cell infiltration in (white) adipose tissue (AT) during obesity is associated with the development of insulin resistance. In AT, the main population of leukocytes are macrophages. Macrophages can be classified into two major populations: M1, classically activated macrophages, and M2, alternatively activated macrophages, although recent studies have identified a broad range of macrophage subsets. During obesity, AT M1 macrophage numbers increase and correlate with AT inflammation and insulin resistance. Upon activation, pro-inflammatory M1 macrophages induce aerobic glycolysis. By contrast, in lean humans and mice, the number of M2 macrophages predominates. M2 macrophages secrete anti-inflammatory cytokines and utilize oxidative metabolism to maintain AT homeostasis. Here, we review the immunologic and metabolic functions of AT macrophages and their different facets in obesity and the metabolic syndrome. (AU)

FAPESP's process: 15/18121-4 - Relationship between obesity and intestinal lamina propria cells function in insulin resistance development
Grantee:Angela Castoldi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/15682-4 - Sepsis and Obesity: study of the relationship between obesity and immune regulation in an experimental model of sepsis
Grantee:Angela Castoldi
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/10910-7 - mTOR signaling pathway in neutrophils during inflammation experimental model associated with obesity
Grantee:Cristiane Naffah de Souza
Support type: Scholarships in Brazil - Doctorate