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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The influence of hubs in the structure of a neuronal network during an epileptic seizure

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Rodrigues, Abner Cardoso [1, 2] ; Cerdeira, Hilda A. [3] ; Machado, Birajara Soares [1]
Total Authors: 3
[1] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[2] Univ Sao Paulo, Bioinformat Interunits Grad Program, Sao Paulo - Brazil
[3] Univ Estadual Paulista, Inst Fis Teor, Rua Pamplona 145, BR-01405 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: European Physical Journal-Special Topics; v. 225, n. 1, p. 75-82, FEB 2016.
Web of Science Citations: 3

In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state. (AU)

FAPESP's process: 11/11973-4 - ICTP South American Institute for Fundamental Research: a regional center for theoretical physics
Grantee:Nathan Jacob Berkovits
Support type: Research Projects - Thematic Grants