| Full text | |
| Author(s): |
Fábio dos Santos Schlottfeldt
[1]
;
Sheila Marques Fernandes
[2]
;
Daniel Malisani Martins
[3]
;
Priscilla Cordeiro
[4]
;
Cassiane Dezoti da Fonseca
[5]
;
Mirian Watanabe
[6]
;
Maria de Fatima Fernandes Vattimo
[7]
Total Authors: 7
|
| Affiliation: | [1] Universidade de São Paulo. Escola de Enfermagem - Brasil
[2] Universidade de São Paulo. Escola de Enfermagem - Brasil
[3] Universidade de São Paulo. Escola de Enfermagem - Brasil
[4] Universidade de São Paulo. Escola de Enfermagem - Brasil
[5] Universidade de São Paulo. Escola de Enfermagem - Brasil
[6] Universidade de São Paulo. Escola de Enfermagem - Brasil
[7] Universidade de São Paulo. Escola de Enfermagem. Departamento de Enfermagem Médico Cirúrgica - Brasil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Revista da Escola de Enfermagem da USP; v. 49, p. 74-79, 2015-12-00. |
| Abstract | |
ABSTRACT Objective To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys. (AU) | |
| FAPESP's process: | 13/26560-2 - Iodinated contrast induced acute kidney injury in diabetic and nephropathy diabetic in rats |
| Grantee: | Maria de Fatima Fernandes Vattimo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/24028-6 - EFFECT OF PHOSPHODIESTERASE-5 INIBITOR IN ISCHEMIC ACUTE KIDNEY INJURY IN RATS |
| Grantee: | Mirian Watanabe |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |