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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between academic performance and cognitive dysfunction in patients with juvenile systemic lupus erythematosus

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Author(s):
Renan Bazuco Frittoli [1] ; Karina de Oliveira Peliçari [2] ; Bruna Siqueira Bellini [3] ; Roberto Marini [4] ; Paula Teixeira Fernandes [5] ; Simone Appenzeller
Total Authors: 6
Affiliation:
[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Rheumatology Laboratory - Brasil
[2] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Rheumatology Laboratory - Brasil
[3] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Rheumatology Laboratory - Brasil
[4] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Pediatric Rheumatology Unit - Brasil
[5] Universidade Estadual de Campinas. Faculdade de Educação Física. Department of Sports Sciences - Brasil
Total Affiliations: 6
Document type: Journal article
Source: REVISTA BRASILEIRA DE REUMATOLOGIA; v. 56, n. 3, p. 252-257, 2016-06-00.
Abstract

Abstract Objective To determine whether there is an association between the profile of cognitive dysfunction and academic outcomes in patients with juvenile systemic lupus erythematosus (JSLE). Methods Patients aged ≤18 years at the onset of the disease and education level at or above the fifth grade of elementary school were selected. Cognitive evaluation was performed according to the American College of Rheumatology (ACR) recommendations. Symptoms of anxiety and depression were assessed by Beck scales; disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI); and cumulative damage was assessed by Systemic Lupus International Collaborating Clinics (SLICC). The presence of autoantibodies and medication use were also assessed. A significance level of 5% (p < 0.05) was adopted. Results 41 patients with a mean age of 14.5 ± 2.84 years were included. Cognitive dysfunction was noted in 17 (41.46%) patients. There was a significant worsening in mathematical performance in patients with cognitive dysfunction (p = 0.039). Anxiety symptoms were observed in 8 patients (19.51%) and were associated with visual perception (p = 0.037) and symptoms of depression were observed in 1 patient (2.43%). Conclusion Patients with JSLE concomitantly with cognitive dysfunction showed worse academic performance in mathematics compared to patients without cognitive impairment. (AU)

FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
Grantee:Simone Appenzeller
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 11/03788-2 - Longitudinal evaluation of interleukins 4, 6, 10 and 12, interferon gamma and tumor necrosis factor alpha and laboratory and clinical associations in systemic lupus erythematosus
Grantee:Mariana Postal Zink de Souza
Support Opportunities: Scholarships in Brazil - Doctorate