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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute exercise restores insulin clearance in diet-induced obese mice

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Kurauti, Mirian A. [1] ; Costa-Junior, Jose M. [1] ; Ferreira, Sandra M. [1] ; dos Santos, Gustavo J. [1] ; Protzek, Andre O. P. [1] ; Nardelli, Tarlliza R. [1] ; de Rezende, Luiz F. [1] ; Boschero, Antonio C. [1]
Total Authors: 8
[1] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Endocrinology; v. 229, n. 3, p. 221-232, JUN 2016.
Web of Science Citations: 11

The aim of this study was to investigate the insulin clearance in diet-induced obese (DIO) mice submitted to acute endurance exercise (3 h of treadmill exercise at 60-70% VO(2)max). Glucose-stimulated insulin secretion in isolated islets; ipGTT; ipITT; ipPTT; in vivo insulin clearance; protein expression in liver, skeletal muscle, and adipose tissue (insulin degrading enzyme (IDE), insulin receptor subunit beta (IR beta), phospho-Akt (p-Akt) and phospho-AMPK (p-AMPK)), and the activity of IDE in the liver and skeletal muscle were accessed. In DIO mice, acute exercise reduced fasting glycemia and insulinemia, improved glucose and insulin tolerance, reduced hepatic glucose production, and increased p-Akt protein levels in liver and skeletal muscle and p-AMPK protein levels in skeletal muscle. In addition, insulin secretion was reduced, whereas insulin clearance and the expression of IDE and IR beta were increased in liver and skeletal muscle. Finally, IDE activity was increased only in skeletal muscle. In conclusion, we propose that the increased insulin clearance and IDE expression and activity, primarily, in skeletal muscle, constitute an additional mechanism, whereby physical exercise reduces insulinemia in DIO mice. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/21283-0 - The role of the IL-6 on the insulin clearance in obese mice submitted to acute exercise
Grantee:Mirian Ayumi Kurauti
Support type: Scholarships in Brazil - Master