BINARY, TERNARY AND QUATERNARY INCLUSION COMPLEXES CONTAINING Lippia sidoides ESSENTIAL OIL

Author(s)

Cláudia R. F. Souza ^[1] ; Patrícia N. Ferraz-Freitas ^[2] ; Wanderley P. Oliveira ^[3]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Ciências Farmacêuticas - Brasil

^[2] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Ciências Farmacêuticas - Brasil

^[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Ciências Farmacêuticas - Brasil

• Document type: Journal article
• Source: Química Nova; v. 39, n. 8, p. 979-986, 2016-09-00.

Abstract

The aim of this work was the production and characterization of binary, ternary and quaternary complexes based on β-cyclodextrin (β-CD) and Lippia sidoides essential oil (EO). OE:β-CD formulations at proportions of 1:10 to 2:10 (binary); added with surfactant or polymer (ternary) or with both (quaternary) were prepared and submitted to spray drying at optimized operating conditions (inlet gas temperature: 160 °C, drying gas flow rate: 60 m3/h; feed flow rate: 4 g/min; pressure and flow rate of the atomizing air: 2.5 kgf/cm2 and 17 lpm). The responses evaluated were the encapsulation efficiency (EE), powder properties, product morphology, and process efficiency (REC). The results showed that the addition of polymer and surfactant to β-CD, generating ternary and quaternary complexes improved the encapsulation efficiency, drying yield, and modify the particles morphology. Samples with lower EO: β-CD ratio (1:10) showed high encapsulation efficiency. (AU)

• FAPESP's process: 11/10333-1 - Microencapsulation and nanoencapsulation of natural compounds by drying technologies
• Grantee: Cláudia Regina Fernandes de Souza
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 14/15905-1 - Encapsulation of essential oils in solid lipid carriers: technological development and applications
• Grantee: Wanderley Pereira Oliveira
• Support Opportunities: Regular Research Grants