| Full text | |
| Author(s): |
Fernandes Marques Bianco, Otavio Augusto
;
Manzine, Patricia Regina
;
Crispim Nascimento, Carla Manuela
;
Carvalho Vale, Francisco Assis
;
Iost Pavarini, Sofia Cristina
;
Cominetti, Marcia Regina
Total Authors: 6
|
| Document type: | Journal article |
| Source: | INTERNATIONAL PSYCHOGERIATRICS; v. 28, n. 6, p. 939-944, JUN 2016. |
| Web of Science Citations: | 5 |
| Abstract | |
Background: Studies have demonstrated a decreased platelet ADAM10 expression in patients with Alzheimer's Disease (AD), classifying this protein as a blood-based AD biomarker. About 50% of the patients with AD are diagnosed with depression, which is commonly treated with tricyclic and tetracyclic antidepressants, monoaminoxidade (MAO) inhibitors and, more preferably, with selective serotonin reuptake inhibitors (SSRIs). Considering that a large proportion of patients with AD takes antidepressant medications during the course of the disease we investigated the influence of this medication on the expression of platelet ADAM10, which is considered the main alpha-secretase preventing beta-amyloid (beta A) formation. Methods: Blood was collected for protein extraction from platelets. ADAM10 was analyzed by using western blotting and reactive bands were measured using beta-actin as endogenous control. Results: Platelet ADAM10 protein expression in patients with AD was positively influenced by serotoninergic medication. Conclusion: More studies on the positive effects of serotonergic antidepressants on ADAM10 platelet expression should be performed in order to understand its biological mechanisms and to verify whether these effects are reflected in the central nervous system. This work represents an important advance for the study of AD biomarkers, as well as for more effective pharmacological treatment of patients with AD and associated depression. (AU) | |
| FAPESP's process: | 10/09497-7 - Platelet levels of ADAM10 in tracking Alzheimer's disease: contributions for nursing care |
| Grantee: | Sofia Cristina Iost Pavarini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/01936-7 - Influence of antidepressants on ADAM10 platelet levels in Alzheimer's Disease |
| Grantee: | Otávio Augusto Fernandes Marques Bianco |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 14/21066-2 - Gene expression of inflammatory cytokine and of microRNA as potential biomarkers of frailty in elderly inserted in a social vulnerability context. |
| Grantee: | Carla Manuela Crispim Nascimento |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/06879-4 - Blood biomarkers for Alzheimer's Disease: evaluation of ADAM10 gene expression and microRNAs |
| Grantee: | Márcia Regina Cominetti |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/08654-7 - Blood biomarkers for Alzheimer's Disease: evaluation of ADAM10 gene expression and micro-RNAs |
| Grantee: | Patricia Regina Manzine Moralles |
| Support Opportunities: | Scholarships in Brazil - Doctorate |