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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis

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Betim Cazarin, Cinthia Bau ; Rodriguez-Nogales, Alba ; Algieri, Francesca ; Pilar Utrilla, M. ; Elena Rodriguez-Cabezas, M. ; Garrido-Mesa, Jose ; Guerra-Hernandez, Eduardo ; de Campos Braga, Patricia Aparecida ; Reyes Reyes, Felix Guillermo ; Marostica, Jr., Mario Roberto ; Galvez, Julio
Total Authors: 11
Document type: Journal article
Source: Journal of Functional Foods; v. 26, p. 565-576, OCT 2016.
Web of Science Citations: 7
Abstract

Low dietary fibre intake has been associated with inflammatory bowel disease incidence. Passiflora edulis peel is considered to be a functional food because of its level of dietary fibre and polyphenols. Female C57BL/6J mice were assigned to three different groups: healthy, dextran sodium sulphate (DSS)-control, and Passiflora edulis treated. Treatment with P. edulis peel flour (8 mg/mL in the drinking water) started 2 weeks before colitis induction, which was performed by adding DSS in the drinking water (3%) for 5 days. P. edulis peel intake exerted an intestinal anti-inflammatory effect and attenuated the colonic damage caused by the DSS, as shown by the reduced disease activity index (DAI) values and after histological evaluation. Biochemical and molecular analyses revealed reduced expression of pro-inflammatory cytokine expression and enhanced intestinal protective barrier. Besides these effects, increases in short-chain fatty acid formation were observed, thus supporting a prebiotic effect. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/24262-1 - Evaluation of the in vitro fermentation of passion fruit peel and its role in intestinal inflammation
Grantee:Cinthia Baú Betim Cazarin
Support type: Scholarships abroad - Research Internship - Doctorate