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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial

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de Araujo Lima Barbosa, Milena Maria ; Trinanes Raposo, Alexandra Lorenzzi ; Teixeira Damasceno, Nagila Raquel
Total Authors: 3
Document type: Journal article
Source: NUTRITION; v. 34, p. 7-13, FEB 2017.
Web of Science Citations: 8

Objective: The aim of this study was to analyze whether omega-3 supplementation improves cardiometabolic profile in individuals with cardiovascular risk factors and to determine the effect of adiponectin levels on these changes. Methods: In this double-blind, placebo-controlled, 2-mo clinical trial, we randomized 80 individuals of both sexes (mean age 52 y) with at least one cardiovascular risk factor (excess weight, hypertension, dyslipidemia, diabetes, or smoking) into two groups: omega-3 (supplemented with 3 g/d of fish oil containing 37% eicosapentaenoic acid and 23% docosahexaenoic acid) and placebo (3 g/d of sunflower oil containing 65% linoleic acid). At baseline and after the intervention, we evaluated serum adiponectin, leptin, lipid profile, apolipoproteins (apo), electronegative low-density lipoprotein (LDL{[}-]), and glucose metabolism (glucose and insulin). Results: After supplementation, the omega-3 group showed an increase in serum adiponectin. After stratifying the omega-3 group by adiponectin concentration at baseline, participants with lower adiponectin concentration showed a higher reduction of total cholesterol, LDL, LDL/high-density lipoprotein ratio, LDL/apo B, and LDL(-). Individuals with a higher variation of adiponectin concentration after omega-3 supplementation presented with reduced blood glucose. The variation of serum adiponectin induced by omega-3 supplementation was negatively correlated with the Framingham and Adult Treatment Panel IV scores (r = -0.4 and P < 0.05 for both). Conclusions: Adiponectin is shown as one of the mechanisms by which omega-3 improves cardiometabolic profile in persons with cardiovascular risk. Moreover, the benefit varies according to the adiponectin basal level and adiponectin variation after supplementation. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/12523-2 - Physical and chemical properties of LDL and HDL, cardiometabolic and oxidative markers can be modulate by consumption of ômega-3, ômega-6 e ômega-9 in adult subjects?
Grantee:Nágila Raquel Teixeira Damasceno
Support type: Regular Research Grants