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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multiple uses of fibrin sealant for nervous system treatment following injury and disease

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Author(s):
Biscola, Natalia Perussi ; Cartarozzi, Luciana Politti ; Ulian-Benitez, Suzana ; Barbizan, Roberta ; Castro, Mateus Vidigal ; Spejo, Aline Barroso ; Ferreira, Jr., Rui Seabra ; Barraviera, Benedito ; Rodrigues Oliveira, Alexandre Leite
Total Authors: 9
Document type: Review article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 23, n. 1 MAR 14 2017.
Web of Science Citations: 19
Abstract

Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery. To date, several studies have demonstrated that human blood derived fibrin sealant produces positive effects in different interventions, becoming an efficient alternative to suturing. To provide an alternative to homologous fibrin sealants, the Center for the Study of Venoms and Venomous Animals (CEVAP, Brazil) has proposed a new bioproduct composed of certified animal components, including a thrombin-like enzyme obtained from snake venom and bubaline fibrinogen. Thus, the present review brings up to date literature assessment on the use of fibrin sealant for nervous system repair and positions the new heterologous bioproduct from CEVAP as an alternative to the commercial counterparts. In this way, clinical and pre-clinical data are discussed in different topics, ranging from central nervous system to peripheral nervous system applications, specifying positive results as well as future enhancements that are necessary for improving the use of fibrin sealant therapy. (AU)

FAPESP's process: 12/20456-6 - The involvement of the major histocompatibility complex class I molecules in the astrocytic reactivity after sciatic nerve transection
Grantee:Sérgio Luiz Oliveira Nunes
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/23377-7 - Neuroprotective and regenerative effects of fibrin sealant derived from snake venom combined with mononuclear stem cells after neurorrhaphy of the sciatic nerve of neonatal rats
Grantee:Natália Perussi Biscola
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 09/53846-9 - Recent acquisition of preparative high-performance liquid chromatograph for the purification and isolation of serine proteinases to produce fibrin sealant
Grantee:Benedito Barraviera
Support type: Multi-user Equipment Program
FAPESP's process: 10/00729-2 - The use of a fibrin sealant combined with bonemarrow mononuclear stem cells to repair motor roots after avulsion in the interface of CNS/PNS
Grantee:Roberta Barbizan Petinari
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/23030-2 - Application of human embryonic stem cells overexpressing FGF2 after ventral root avulsion: neuroprotection and immunomodulation
Grantee:Marta Rocha Araujo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/11405-4 - Alpha/gamma motoneuron survival rate and plasticity following neonatal sciatic nerve axotomy
Grantee:Natália Perussi Biscola
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 12/02689-3 - Use of fibrin sealant associated with hydroxyapatite in repair of bone defects induced in rat calvaria
Grantee:Fernanda de Araujo Menezes
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/08101-8 - In vivo imaging of nerve regeneration following ventral root replantation with fluo-stained fibrin sealant associated with mesenchymal stem cells
Grantee:Rui Seabra Ferreira Junior
Support type: Regular Research Grants
FAPESP's process: 14/06892-3 - Use of mesenchymal stem cells in the CNS/PNS interface: repair of proximal lesions
Grantee:Alexandre Leite Rodrigues de Oliveira
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/04409-0 - Comparative study on the use of commercial and snake venon derived fibrin sealant for reimplantation of spinal cord ventral roots following avulsion
Grantee:Mateus Vidigal de Castro
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/22750-9 - Use of fibrin sealant combined with mesenchymal stem cells for anterior funiculus injury repair: effects on inflammation, axonal regeneration and neuroprotection.
Grantee:Aline Barroso Spejo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/13514-0 - Analysis of cellular mechanisms of acute injuries in the central and peripheral nervous system using novel imaging approaches
Grantee:Luciana Politti Cartarozzi
Support type: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 11/02889-0 - Use of fibrin sealant combined with mesenchymal stem cells in the repair of peripheral nerves through tubulization technique
Grantee:Luciana Politti Cartarozzi
Support type: Scholarships in Brazil - Master