Congenital deformities, trauma and tumors with significant loss of bone mass can be repaired using autograft. However, their use may become limited due to some disadvantages, such as chronic pain and necrosis of the donor area. Thus, the synthetic biomaterials are a viable alternative to grafting. Among these materials, stands out for its biocompatibility and hydroxyapatite composition similar to bone. Another substance with osteogenic potential is likely fibrin sealant due to its healing properties acting as an adhesive to the fabric and probable carrier for cell proliferation. Thus, this study aimed at assessing the process of bone formation during the repair of cranial bone defects grafted with fibrin sealant and hydroxyapatites. To this, 32 rats will be used. The animals will undergo the surgical procedure to create a critical bone defect in the skull to be filled with fibrin sealant and hydroxyapatite. 2 and 6 weeks after surgery, the animals will be sacrificed and samples of the receiving area of the implants will undergo radiological analyzes, histological and morphometric.Keywords: Biomaterials, hidroxyapatite, osteogenesis, osteointegration, bone regeneration, fibrin sealants.
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