| Full text | |
| Author(s): |
Mafud, Ana Carolina
;
Reinheimer, Eric W.
;
Dalmatti Alves Lima, Filipe Camargo
;
Batista, Larissa Fernandes
;
de Paula, Karina
;
Costa Veras, Leiz Maria
;
de Souza de Almeida Leite, Jose Roberto
;
Venancio, Tiago
;
Mascarenhas, Yvonne Primerano
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Journal of Molecular Structure; v. 1136, p. 204-213, MAY 15 2017. |
| Web of Science Citations: | 0 |
| Abstract | |
Epiisopiloturine hydrochloride (Epi-HCl) salt was synthetized from epiisopiloturine, an in vivo anthelmintic compound against Schistosoma mansoni worms. Despite there being no acute toxicity in mammalian cells, the compound's water insolubility makes its administration difficult. In this communication, we report the characterization of Epi-HCl its features by spectroscopy, thermal analysis, and PXRD. The single crystals suitable to X-ray diffraction were grown by slow evaporation technique. To better understand the nature of Epi-HCl solid state, SS-NMR was also used. The salt's intramolecular structure was maintained via cation-pi intramolecular interactions, which in conjunction with hydrogen bonding, gives rise to an extended supramolecular assembly. The interatomic distances within the cations and environment around the chloride anion vary as function of temperature, suggesting a packing relaxation. (C) 2017 Published by Elsevier B.V. (AU) | |
| FAPESP's process: | 14/02282-6 - Structure-activity relationship studies about of Pilocarpus microphyllus (Rutaceae) alkaloid derivatives against Schistosoma mansoni |
| Grantee: | Ana Carolina Mafud |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery |
| Grantee: | Glaucius Oliva |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |